Convenient synthesis of substituted 3‐aminothiophene‐2‐carbonitriles from α‐acetylenic nitriles and their conversion to thieno[3,2‐d]pyrimidines Journal Article
| Authors: | Ren, W. Y.; Rao, K. V. B.; Klein, R. S. |
| Article Title: | Convenient synthesis of substituted 3‐aminothiophene‐2‐carbonitriles from α‐acetylenic nitriles and their conversion to thieno[3,2‐d]pyrimidines |
| Abstract: | Several novel 2,4,6‐trisubstituted thieno[3,2‐d]pyrimidines were synthesized from the hitherto unknown 3‐amino‐5‐methyl‐(or 5‐phenyl)thiophene‐2‐carbonitriles 7 and 8. o‐Aminonitriles 7 and 8 were obtained in a single step by conjugate addition of mercaptoacetonitrile (generated in situ) to substituted acetylenic nitriles 4 and 5 and annelation of the intermediate vinylic thioethers. Copyright © 1986 Journal of Heterocyclic Chemistry |
| Keywords: | unclassified drug; drug efficacy; nonhuman; biological model; in vitro study; drug screening; drug synthesis; drug cytotoxicity; nuclear magnetic resonance; drug identification; intoxication; drug comparison; new drug; ultraviolet spectrophotometry; leukemia l 1210; thieno[3,2 d]pyrimidine derivative; blood and hemopoietic system; drug analysis; 2,4 diamino 6 phenylthieno[2,3 d]pyrimidine; 3 amino 2 thiophenecarbonitrile derivative; p 815 cell |
| Journal Title: | Journal of Heterocyclic Chemistry |
| Volume: | 23 |
| Issue: | 6 |
| ISSN: | 0022-152X |
| Publisher: | Wiley-Blackwell Publishing, Inc. |
| Date Published: | 1986-11-01 |
| Start Page: | 1757 |
| End Page: | 1763 |
| Language: | English |
| DOI: | 10.1002/jhet.5570230631 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
