Dietary bovine antigens and immune complex formation after intravenous immunoglobulin in common varied immunodeficiency Journal Article


Authors: Cunningham-Rundles, C.; Carr, R. I.
Article Title: Dietary bovine antigens and immune complex formation after intravenous immunoglobulin in common varied immunodeficiency
Abstract: Previously we have shown that the sera of hypogammaglobulinemic patients may contain large amounts of antigenically intact foreign protein of dietary origin, presumably due to the absence of an adequate gastrointestinal secretory immune barrier. In these studies we show that the intravenous infusion of immunoglobulin in these patients may result in high levels of immune complexes postinfusion and that at least one constituent of these complexes is likely to be bovine casein. © 1986 Plenum Publishing Corporation.
Keywords: clinical article; unclassified drug; drug efficacy; animal; immunoglobulin; diet; antigen; immunoglobulin g; cattle; antibodies; infusions, intravenous; immunologic deficiency syndromes; therapy; infusion; intravenous drug administration; oral drug administration; prevention; milk; antigen antibody complex; radioimmunoassay; common variable immunodeficiency; antigen-antibody complex; caseins; intravenous immunoglobulin; hypogammaglobulinemia; human; agammaglobulinemia; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; casein; immune complexes; blood and hemopoietic system; gammastan; bovine casein; complement 1q; complement 3; complement activating enzymes
Journal Title: Journal of Clinical Immunology
Volume: 6
Issue: 5
ISSN: 0271-9142
Publisher: Springer  
Date Published: 1986-09-01
Start Page: 381
End Page: 388
Language: English
DOI: 10.1007/bf00915377
PUBMED: 3490487
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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