Solid phase synthesis of thymosin β9 Journal Article
| Authors: | Chandramouli, N.; Bhargava, K. K.; Incefy, G. S.; Modak, M. J.; Merrifield, R. B. |
| Article Title: | Solid phase synthesis of thymosin β9 |
| Abstract: | Thymosin β9, a 41 residue thymic polypeptide, has been synthesized by a solid phase method. A modification of the low HF method was used to deprotect and cleave the peptide from the resin. Thymosin β9 was then obtained in analytically pure form by a one‐step purification procedure in 32% yield. The activity of thymosin β9 in the terminal deoxynucleotidyl transferase assay was greater than calf thymus fraction 5, but comparable to thymosin β4. In contrast to thymosin α1, neither β4 nor β9 was active in the rosette inhibition assay. © 1986 Munksgaard International Publishers Ltd. |
| Keywords: | mouse; animal; metabolism; mice; enzymology; structure activity relation; structure-activity relationship; mice, inbred c57bl; thymus; thymus gland; drug derivative; hydrocortisone; mouse strain; thymosin; dna nucleotidylexotransferase; synthesis; indicators and reagents; solid phase synthesis; dyes, reagents, indicators, markers and buffers; article; support, u.s. gov't, p.h.s.; in vivo enhancement; terminal deoxynucleotidyl transferase activity; thymosin β 9; thymosin beta(9) |
| Journal Title: | International Journal of Peptide and Protein Research |
| Volume: | 28 |
| Issue: | 5 |
| ISSN: | 0367-8377 |
| Publisher: | Wiley-Blackwell Publishing, Inc. |
| Date Published: | 1986-11-01 |
| Start Page: | 536 |
| End Page: | 541 |
| Language: | English |
| DOI: | 10.1111/j.1399-3011.1986.tb03289.x |
| PUBMED: | 3818171 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
