Immunohistologic expression of blood‐group antigens in normal human gastrointestinal tract and colonic carcinoma Journal Article

  


Authors: Cordon‐Cardo, C.; Lloyd, K. O.; Sakamoto, J.; McGroarty, M. E.; Old, L. J.; Melamed, M. R.
Article Title: Immunohistologic expression of blood‐group antigens in normal human gastrointestinal tract and colonic carcinoma
Abstract: A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood‐group‐related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colorectal carcinomas. The reagents employed detect the following blood‐group specificities: A (all variants), B. H (type 2), Lewisa, Lewisb, × (Lewisx), Y (Lewisy) and type I precursor chain. Immunohistochemical studies demonstrate that these antigens are differentially expressed in various cell types and developmental stages of the human gastrointestinal tract. ABH expression undergoes developmental modulation in the human colorectal tract from positive to negative during embryogenesis, and is lost in adult cells. Colorectal tumors exhibit neosynthesis of ABH specificities that appear in tumor cells, and accumulation of the precursor antigens. They also show increased expression of Lewis antigens, especially Y determinant, which has a restricted pattern of distribution in normal tissues and is not found in normal colonic mucosa. Enhancement of the Lewis antigens is observed in all colorectal tumors analyzed, regardless of blood‐group type and secretory status of the individuals studied. Tumor modulation of these antigens may be related to activation of suppressed genes and enhancement of fucosyltransferases. Copyright © 1986 Wiley‐Liss, Inc., A Wiley Company
Keywords: immunohistochemistry; adult; aged; middle aged; human cell; antigen expression; cytology; colonic neoplasms; abo blood-group system; colorectal carcinoma; immunoenzyme techniques; fluorescent antibody technique; antibodies, monoclonal; carcinoma; colon carcinoma; gastrointestinal tract; rectal neoplasms; lewis blood-group system; intestinal mucosa; digestive system; large intestine; blood group lewis system; lectins; lectin binding; plant lectins; humans; human; male; female; priority journal; blood group antigens; blood group antigen; blood and hemopoietic system
Journal Title: International Journal of Cancer
Volume: 37
Issue: 5
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 1986-05-15
Start Page: 667
End Page: 676
Language: English
DOI: 10.1002/ijc.2910370505
PUBMED: 3516890
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022517145&doi=10.1002%2fijc.2910370505&partnerID=40&md5=ca4c3251572a3c58605ac97044f1f6f3
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Lloyd J Old
    593 Old
  3. Kenneth O Lloyd
    163 Lloyd
  4. Myron Melamed
    148 Melamed
Related MSK Work