Expression of blood group antigens in bladder cancer: Current concepts Journal Article

  


Authors: Sheinfeld, J.; Reuter, V. E.; Fair, W. R.; Cordon-Cardo, C.
Article Title: Expression of blood group antigens in bladder cancer: Current concepts
Abstract: Blood group antigens are a group of carbohydrate structures bound to membrane lipids or proteins of erythrocytes and certain epithelial tissues including urothelium. The Lewis antigens are structures that are genetically and biochemically related to the ABO blood group. The ABO and Lewis blood group systems are differentially expressed in the normal urothelium of “secretors” versus “nonsecretor” individuals. The normal urothelium of “secretors” is rich in ABH, Leb, and Ley antigens while the urothelium of “nonsecretors” does not express these antigens. Therefore, deletion of ABH antigens, commonly noted in TCC, can only be reliably ascertained in “secretor” individuals. Neo‐expression of the Lewis X antigen (which is absent in normal urothelium) is noted in over 85% of TCC regardless of tumor stage and grade. Immunocytological detection of the Lewis X antigen on exfoliated bladder epithelial cells enhances the detection of urothelial tumor cells, particularly from low grade and low stage neoplasms. Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company
Keywords: immunohistochemistry; human cell; gene deletion; review; cancer recurrence; cancer growth; cancer staging; neoplasm staging; cancer grading; gene expression; blood group abo system; abo blood-group system; bladder cancer; urothelium; immunocytochemistry; antigen detection; gene control; bladder neoplasms; lewis x antigen; cytopathology; lewis blood-group system; glycosyltransferase; blood group lewis system; blood group; human; support, u.s. gov't, p.h.s.; blood group antigen; secretor status; bladder tumor detection
Journal Title: Seminars in Surgical Oncology
Volume: 8
Issue: 5
ISSN: 8756-0437
Publisher: John Wiley & Sons  
Date Published: 1992-09-01
Start Page: 308
End Page: 315
Language: English
DOI: 10.1002/ssu.2980080510
PUBMED: 1462102
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026761607&doi=10.1002%2fssu.2980080510&partnerID=40&md5=2f2bd444ce9b974e9f2464c4d96ecf08
Notes: Source: Scopus
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Joel Sheinfeld
    254 Sheinfeld
  3. Victor Reuter
    1228 Reuter
  4. William R Fair
    342 Fair
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