Natural cytotoxic (NC) activity: A multi-lineage system regulated by IL-2 Journal Article
| Authors: | Lattime, E. C.; Bykowsky, M. J.; Stutman, O. |
| Article Title: | Natural cytotoxic (NC) activity: A multi-lineage system regulated by IL-2 |
| Abstract: | The studies described in this report demonstrate that NC activity is the function of a number of distinct effector cell populations and not due to a single type of NC cell. While IL-2 was found to augment the NC activity of all populations tested, in vitro culture and T-deficient mutant mouse studies would suggest that it is not necessary for maintaining NC activity. With NC being an 'activity' rather than the function of a single effector cell type, identifying all populations that lyse the WEHI-164 target as a single type of effector is no longer valid. As discussed previously, the same situation may apply to the NK compartment [43]. © 1986 Humana Press Inc. |
| Keywords: | drug efficacy; nonhuman; comparative study; mouse; animal; mice; cells, cultured; heredity; interleukin 2; mice, mutant strains; b lymphocyte; mice, inbred strains; species specificity; t-lymphocytes, cytotoxic; natural killer cell; killer cells, natural; short survey; cytotoxicity, immunologic; macrophage; interleukin-2; mutant; immunity, natural; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; blood and hemopoietic system |
| Journal Title: | Immunologic Research |
| Volume: | 5 |
| Issue: | 1 |
| ISSN: | 0257-277X |
| Publisher: | Springer |
| Date Published: | 1986-03-01 |
| Start Page: | 5 |
| End Page: | 15 |
| Language: | English |
| DOI: | 10.1007/bf02917189 |
| PUBMED: | 3489796 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors wish to thank Dr. L. Shultz for providing the moth-eaten mice and Dr. G. Koo for the anti-NK-1.1-injected animals. We also thank Mr. C. Mueller and Ms. Kim Ricci for expert technical assistance. |
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