Further definition of the Ly-5 system Journal Article
| Authors: | Shen, F. W.; Tung, J. S.; Boyse, E. A. |
| Article Title: | Further definition of the Ly-5 system |
| Abstract: | Ly-5 is expressed by cells of the hematopoietic branch of development. Further serological analysis of the Ly-5 system, aided by Ly-5 monoclonal antibodies and by two Ly-5 congenic mouse strains, reveals two new Ly-5 alloantigens, Ly-5. 3 and Ly-5.4. The data define three thymocyte phenotypes, Ly-5.1,3, Ly-5.2,4, and Ly-5.2,3, and three corresponding genotypes, Ly-5a, Ly-5b, and Ly-5c, respectively. Ly-5ais by far the most common allele. The Ly-5callele is found only in the ST/bJ strain, a finding that accords with the presently unique pattern of restriction fragments previously observed in Southern blotting of ST/bJ DNA with an Ly-5 cDNA probe. Present serological and biochemical data favor the interpretation that the compound Ly-5 phenotype of thymocytes is attributable to two separate Ly-5 molecular isoforms that exhibit a discrete difference in protein composition, bear different Ly-5 antigens, and are produced jointly by thymocytes, unlike other Ly-5 isoforms previously shown to distinguish different hematopoietic cell lineages. © 1986 Springer-Verlag. |
| Keywords: | nonhuman; t-lymphocytes; animal cell; mouse; animal; cytology; mice; heredity; alleles; cell differentiation; in vitro study; monoclonal antibody; mice, inbred strains; antibodies, monoclonal; thymus; immunoprecipitation; hematopoietic stem cells; alloantigen; thymocyte; antigens, ly; etiology; reticuloendothelial system; sheep; protein a; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; blood and hemopoietic system; hematopoietic cell line |
| Journal Title: | Immunogenetics |
| Volume: | 24 |
| Issue: | 3 |
| ISSN: | 0093-7711 |
| Publisher: | Springer |
| Date Published: | 1986-09-01 |
| Start Page: | 146 |
| End Page: | 149 |
| Language: | English |
| DOI: | 10.1007/bf00364741 |
| PUBMED: | 3489673 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work