Genetic analysis of the T/t complex Journal Article

  


Author: Artzt, K.
Article Title: Genetic analysis of the T/t complex
Abstract: The T/t-complex has held considerable interest for immunologists, primarily because of its close genetic linkage to the major histocompatibility complex (MHC) on mouse chromosome 17. This interest has been heightened recently with the discovery that the MHC is fully contained within the t-complex and that two regions of the MHC, Qa and K, contain t-lethal genes. For a long time, T/t has been an enigmatic system, mainly because classical genetic analysis was not possible. Here the system is defined, recent information is presented, and our understanding of the mouse data to available information about the human MHC is correlated. © 1986.
Keywords: nonhuman; genetic analysis; mouse; animal; mice; heredity; animal experiment; genotype; tail; gene mapping; major histocompatibility complex; chromosome 17; linkage (genetics); gene location; in vitro; genes, lethal; human; priority journal; inversion (genetics)
Journal Title: Human Immunology
Volume: 15
Issue: 4
ISSN: 0198-8859
Publisher: Elsevier Inc.  
Date Published: 1986-04-01
Start Page: 374
End Page: 380
Language: English
DOI: 10.1016/0198-8859(86)90014-5
PUBMED: 3516939
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022641704&doi=10.1016%2f0198-8859%2886%2990014-5&partnerID=40&md5=e1b33d2d5ec5575b602cbeaea315611b
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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