Authors: | Conti, P. S.; Sordillo, P. P.; Schmall, B.; Benua, R. S.; Bading, J. R.; Bigler, R. E.; Laughlin, J. S. |
Article Title: | Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma |
Abstract: | A 29 year-old-man presenting with advanced metastatic malignant melanoma was successfully imaged using carbon-11 (11C) labeled alpha-aminoisobutyric acid (AIB), a synthetic, non-metabolized amino acid transported into viable cells by the A-type, or alanine-preferring, amino acid transport system. Tumor located in the hilum of the lung was well visualized with 11C-AIB prior to chemotherapy. A gallium image with liver subtraction using 99mTc-sulfur colloid demonstrated regions of increased activity in liver which correlated with regions of increased activity on the 11C-AIB liver image. © 1986 Springer-Verlag. |
Keywords: | adult; cancer chemotherapy; unclassified drug; case report; drug efficacy; liver neoplasms; melanoma; metastasis; skin neoplasms; lung neoplasms; lymphatic system; liver metastasis; lung metastasis; liver; drug accumulation; diagnosis; malignant melanoma; radioisotope; gallium citrate ga 67; cancer scintiscanning; mediastinal neoplasms; therapy; pharmacokinetics; technetium sulfur colloid tc 99m; liver scintiscanning; tumor imaging; respiratory system; carbon radioisotopes; aminoisobutyric acids; humans; human; male; article; 2 amino 2 methylpropionic acid c 11; 11c-aib |
Journal Title: | European Journal of Nuclear Medicine |
Volume: | 12 |
Issue: | 7 |
ISSN: | 0340-6997 |
Publisher: | Springer Verlag |
Date Published: | 1986-10-01 |
Start Page: | 353 |
End Page: | 356 |
Language: | English |
DOI: | 10.1007/bf00263819 |
PUBMED: | 3792366 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors wish to thank Mr. J. Robert Dahl and Mr. Richard Lee for their assistance in the production of carbon-11. |