Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma Journal Article

  


Authors: Conti, P. S.; Sordillo, P. P.; Schmall, B.; Benua, R. S.; Bading, J. R.; Bigler, R. E.; Laughlin, J. S.
Article Title: Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma
Abstract: A 29 year-old-man presenting with advanced metastatic malignant melanoma was successfully imaged using carbon-11 (11C) labeled alpha-aminoisobutyric acid (AIB), a synthetic, non-metabolized amino acid transported into viable cells by the A-type, or alanine-preferring, amino acid transport system. Tumor located in the hilum of the lung was well visualized with 11C-AIB prior to chemotherapy. A gallium image with liver subtraction using 99mTc-sulfur colloid demonstrated regions of increased activity in liver which correlated with regions of increased activity on the 11C-AIB liver image. © 1986 Springer-Verlag.
Keywords: adult; cancer chemotherapy; unclassified drug; case report; drug efficacy; liver neoplasms; melanoma; metastasis; skin neoplasms; lung neoplasms; lymphatic system; liver metastasis; lung metastasis; liver; drug accumulation; diagnosis; malignant melanoma; radioisotope; gallium citrate ga 67; cancer scintiscanning; mediastinal neoplasms; therapy; pharmacokinetics; technetium sulfur colloid tc 99m; liver scintiscanning; tumor imaging; respiratory system; carbon radioisotopes; aminoisobutyric acids; humans; human; male; article; 2 amino 2 methylpropionic acid c 11; 11c-aib
Journal Title: European Journal of Nuclear Medicine
Volume: 12
Issue: 7
ISSN: 0340-6997
Publisher: Springer Verlag  
Date Published: 1986-10-01
Start Page: 353
End Page: 356
Language: English
DOI: 10.1007/bf00263819
PUBMED: 3792366
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022896843&doi=10.1007%2fBF00263819&partnerID=40&md5=3b49ae019efacb147cb72e5bb875b414
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors wish to thank Mr. J. Robert Dahl and Mr. Richard Lee for their assistance in the production of carbon-11.
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. John S Laughlin
    20 Laughlin
  2. Peter S. Conti
    14 Conti
  3. Peter P. Sordillo
    20 Sordillo
  4. James Bading
    17 Bading
Related MSK Work