Chondrosarcoma Journal Article
| Authors: | Healey, J. H.; Lane, J. M. |
| Article Title: | Chondrosarcoma |
| Abstract: | Chondrosarcoma is a malignant cartilage-forming tumor that affects predominently the middle-aged population. There are three histologic grades, but differentiation of Grade I tumors from enchondromas can be difficult. The measurement of polypoidy (augmented chromosomal content per cell) appears to offer a method of segregation of benign from low-grade from high-grade tumors. With the exception of the high-grade spindle elements, current chemotherapy does not appear to affect chondrosarcomas. Retinoic acid, however, by enhancing lysosomal enzyme release, may be a potential efficacious therapeutic agent. Enhanced tumor staging as provided by the computed tomographic (CT) scan has demonstrated the boundaries for wide surgical excisions, most notably internal hemipelvectomies for low- and moderate-grade pelvic chondrosarcomas. Currently, low-grade chondrosarcomas have an overall five-year survival of 65%-85% in contradistinction to 15% for the highest grade chondrosarcomas. |
| Keywords: | major clinical study; cancer staging; computer assisted tomography; diagnosis; bone; chondrosarcoma; retinoic acid; therapy; computer analysis; human; priority journal |
| Journal Title: | Clinical Orthopaedics and Related Research |
| Volume: | 204 |
| ISSN: | 0009-921X |
| Publisher: | Springer |
| Date Published: | 1986-03-01 |
| Start Page: | 119 |
| End Page: | 129 |
| Language: | English |
| DOI: | 10.1097/00003086-198603000-00012 |
| PUBMED: | 3956003 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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