Modulation of the immune response by immunoglobulin for intravenous use. II. Inhibitory effects of sera from treated patients Journal Article
| Authors: | Stohl, W.; Cunningham-Rundles, C.; Thompson, C.; Mayer, L. |
| Article Title: | Modulation of the immune response by immunoglobulin for intravenous use. II. Inhibitory effects of sera from treated patients |
| Abstract: | Sera were collected from patients with common varied immunodeficiency (CVI) prior to and following intravenous γ-globulin (IVGG) infusion. Cultures of pokeweed mitogen (PWM)-stimulated peripheral blood mononuclear cells from normal donors in medium containing post-IVGG infusion sera generated significantly fewer plaque-forming cells (PFC) than those cultures in medium containing the corresponding pre-IVGG infusion sera. However, preinfusion CVI sera were found to be similar to normal sera in their capacities to support PWM-induced PFC generation, despite the disparity in Ig levels between the two groups of sera. Furthermore, serum collected from a CVI patient 24 hr or more after IVGG infusion no longer possessed the same inhibitory capacity as serum collected 10 min after IVGG infusion despite elevated IgG levels compared to baseline. These studies suggest that IVGG infusion may induce an immunosuppressive effect which is transient in nature, raising the possibility of in vivo counterbalancing homeostatic mechanisms responding to this immune perturbation. © 1986. |
| Keywords: | unclassified drug; human cell; t-lymphocytes; immunoglobulin; cell differentiation; time factors; b-lymphocytes; immune response; immunotherapy; mononuclear cell; immunoglobulin g; immune deficiency; drug therapy; immunologic deficiency syndromes; therapy; intravenous drug administration; human experiment; immunity, cellular; lymphocyte transformation; common variable immunodeficiency; b lymphocyte differentiation factor; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; plaque forming cell; gamma-globulins; gammonativ; pokeweed mitogen; antibody-producing cells; blood and hemopoietic system |
| Journal Title: | Clinical Immunology and Immunopathology |
| Volume: | 41 |
| Issue: | 2 |
| ISSN: | 0090-1229 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1986-11-01 |
| Start Page: | 273 |
| End Page: | 280 |
| Language: | English |
| DOI: | 10.1016/0090-1229(86)90111-x |
| PUBMED: | 2429797 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors thank Susan Mechanic for excellent technical assistance: Alise Lion-Boule, Susan Gluckman, Robin Tauer, and Jill Burgess for nursing assistance; Sandoz, Kabi-Vitrum, and Alpha Therapeutics for supplying IVGG for in view use; and Dr. Mark Grebenau of Sandoz for supplying Sandoglobulin for in vitro studies. |
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