Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies Journal Article
| Authors: | Björkander, J.; Hammarström, L.; Smith, C. I. E.; Buckley, R. H.; Cunningham-Rundles, C.; Hanson, L. Å |
| Article Title: | Immunoglobulin prophylaxis in patients with antibody deficiency syndromes and anti-IgA antibodies |
| Abstract: | Sera from three hundred five patients with immunoglobulin deficiencies were analyzed for the presence of anti-IgA antibodies by using indirect agglutination and enzyme-linked immunosorbent assay (ELISA). Anti-IgA antibodies were observed in 15 of 68 (22%) patients with hypogammaglobulinemia and 53 of 185 (29%) patients with selective IgA deficiency, both groups having serum IgA<0.05 g/liter. The highest frequency, 6 of 10 or 60%, was noted for patients with a combined IgA-IgG2 deficiency. No anti-IgA antibodies were detected in 25 patients with serum IgA between 0.05 and 0.27 g/liter and normal amounts of serum IgM and IgG or in 17 patients with hypogammaglobulinemia who had serum IgA of 0.05-0.7 g/liter. The anti-IgA antibodies were primarily of the IgG class, but IgD and IgM anti-IgA were occasionally found. IgE anti-IgA antibodies could not be detected with the presently used technique. The IgG anti-IgA antibodies were mainly of the IgG1 subclass but occasionally also of the subclasses IgG2, IgG3, and IgG4. Of eight patients with anti-IgA antibodies, seven tolerated Ig prophylaxis with a commercial immunoglobulin preparation low in IgA when given either intramuscularly or intravenously. The titers of anti-IgA in the sera of these patients did not rise in relation to the prophylaxis. Only one of the eight patients had a history of previous anaphylactic reactions to IgA-containing blood products. He tolerated six Ig infusions during 5 months with the IgA-depleted preparation without any adverse effects but showed increasing levels of anti-IgA antibodies and ultimately experienced a near-fatal reaction at the seventh infusion. © 1987 Plenum Publishing Corporation. |
| Keywords: | unclassified drug; major clinical study; immunoglobulin; blood; immunotherapy; immunoglobulin g; diagnosis; blood transfusion; immune deficiency; drug therapy; immunoglobulin deficiency; anaphylaxis; adverse drug reaction; immunologic deficiency syndromes; therapy; intravenous drug administration; immunoglobulins; immunization; immunoglobulin a; immunoprophylaxis; antibodies, anti-idiotypic; immunization, passive; immunoglobulin a antibody; immunoglobulin a deficiency; hypogammaglobulinemia; humans; human; article; agammaglobulinemia; immunoglobulin isotypes; igg deficiency; blood and hemopoietic system; adverse effects of immunoglobulins; iga deficiency; immunodeficiency syndromes; immunoglobulin g2 antibody |
| Journal Title: | Journal of Clinical Immunology |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 0271-9142 |
| Publisher: | Springer |
| Date Published: | 1987-01-01 |
| Start Page: | 8 |
| End Page: | 15 |
| Language: | English |
| DOI: | 10.1007/bf00915419 |
| PUBMED: | 3494039 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work