Development of T-cell function in relation to T-cell set diversification in nu/nu mice Journal Article
| Authors: | Ranges, G. E.; Palladino, M. A. Jr; Scheid, M. P. |
| Article Title: | Development of T-cell function in relation to T-cell set diversification in nu/nu mice |
| Abstract: | The differentiation pattern of splenic T-cell populations in germ- and pathogen-free nu/nu mice, as compared to nu/+ littermates, is characterized by two abnormal features: (i) the expression of TL determinants on peripheral T cells and (ii) the delayed onset of their differentiation from the predominant Lyt-123:TL+ set into TL- cells of Lyt-1+ and Lyt-123+ phenotype, which, in these mice, does not occur until 10 weeks of age. We report here that the delayed onset of mitogen- or alloantigen-induced interleukin-2 synthesis and T-cell proliferation as well as the development of cytotoxic T-lymphocyte activity of enriched T-cell populations is strictly correlated with the time point of T-cell subset diversification in nu/nu mice and depends in particular on the presence of the Lyt-1 (TL-:Lyt-2-) T-cell set which is lacking in splenic T-cell populations of germ-free young nu/nu mice. © 1986. |
| Keywords: | nonhuman; t lymphocyte; t-lymphocytes; mouse; phenotype; animal; mice; interleukin 2; spleen; age factors; age; lymphocyte activation; mice, nude; peptide fragments; cytotoxic t lymphocyte; t lymphocyte subpopulation; interleukin-2; interleukin-1; concanavalin a; priority journal; support, u.s. gov't, p.h.s.; thymopentin; thymopoietins; t-lymphocytes, suppressor-effector |
| Journal Title: | Cellular Immunology |
| Volume: | 98 |
| Issue: | 2 |
| ISSN: | 0008-8749 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1986-04-01 |
| Start Page: | 496 |
| End Page: | 505 |
| Language: | English |
| DOI: | 10.1016/0008-8749(86)90308-4 |
| PUBMED: | 2944619 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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