Increased N-myc expression following progressive growth of human neuroblastoma Journal Article
| Authors: | Rosen, N.; Reynolds, C. P.; Thiele, C. J.; Biedler, J. L.; Israel, M. A. |
| Article Title: | Increased N-myc expression following progressive growth of human neuroblastoma |
| Abstract: | Many human neuroblastoma tumors and cells in culture contain amplified N-myc DNA and this is associated with tumor stage. We have analyzed pairs of neuroblastoma cell cultures derived from two patients at the time of diagnosis and after tumor progression following the initiation of therapy. Cell cultures derived after progression have increased expression of N-myc RNA. In one pair this increase is associated with increased N-myc DNA amplification; in the other, amplification decreases and activation of N-myc is most likely the result of a regulatory change. Analysis of the pattern of DNA amplification in these cell cultures demonstrates additional changes that might be associated with tumor progression. copyright. © 1986, American Association for Cancer Research. All rights reserved. |
| Keywords: | human cell; heredity; gene amplification; gene expression; cell line; in vitro study; rna; oncogene; cell culture; neuroblastoma; rna, messenger; dna, neoplasm; base sequence; tumor growth; therapy; nervous system; proto-oncogenes; humans; human; priority journal |
| Journal Title: | Cancer Research |
| Volume: | 46 |
| Issue: | 8 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1986-08-01 |
| Start Page: | 4139 |
| End Page: | 4142 |
| Language: | English |
| PUBMED: | 3731081 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
