Chromosome breakage in Fanconi's anemia and normal cells following in vitro and in vivo cocultivation Journal Article

  


Authors: Shaham, M.; Adler, B.
Article Title: Chromosome breakage in Fanconi's anemia and normal cells following in vitro and in vivo cocultivation
Abstract: Studies of Fanconi's anemia (FA) have been in conflict as to the existence of a clastogenic factor. Two male FA patients who received bone marrow transplants were studied. One FA patient received a transplant from his normal sister whose engrafted lymphocytes showed spontaneous, as well as diepoxybutane (DEB)-induced chromosome breakage in the normal range. The second FA patient received a transplant from his obligate heterozygous mother whose engrafted lymphocytes exhibited increased spontaneous chromosome breakage but not in response to DEB treatment. In vitro cocultivation of FA and FA heterozygous lymphocytes and of FA and normal lymphocytes showed chromosome breakage levels consistent with their genotypes. These results suggest that no detectable clastogenic factor is produced by FA cells. © 1986.
Keywords: adolescent; child; child, preschool; human cell; cells, cultured; heredity; in vitro study; histology; cell culture; chromosome breakage; chromosome aberrations; bone marrow transplantation; lymphocytes; fanconi anemia; anemia, aplastic; human; male; female; priority journal; support, u.s. gov't, p.h.s.; blood and hemopoietic system
Journal Title: Cancer Genetics and Cytogenetics
Volume: 23
Issue: 4
ISSN: 0165-4608
Publisher: Elsevier Science, Inc.  
Date Published: 1986-12-01
Start Page: 315
End Page: 320
Language: English
DOI: 10.1016/0165-4608(86)90014-2
PUBMED: 3536074
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023007120&doi=10.1016%2f0165-4608%2886%2990014-2&partnerID=40&md5=e7c7f65932362b6d6bc4391c439fecf5
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors are grateful to Dr. R. S. K. Chaganti for careful reading and reviewing of this manuscript.
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
Related MSK Work