Myelodysplastic syndrome, acute myeloid leukemia, and cancer surveillance in Fanconi anemia Journal Article
| Authors: | Savage, S. A.; Walsh, M. F. |
| Article Title: | Myelodysplastic syndrome, acute myeloid leukemia, and cancer surveillance in Fanconi anemia |
| Abstract: | Fanconi anemia (FA) is a DNA repair disorder associated with a high risk of cancer and bone marrow failure. Patients with FA may present with certain dysmorphic features, such as radial ray abnormalities, short stature, typical facies, bone marrow failure, or certain solid malignancies. Some patients may be recognized due to exquisite sensitivity after exposure to cancer therapy. FA is diagnosed by increased chromosomal breakage after exposure to clastogenic agents. It follows autosomal recessive and X-linked inheritance depending on the underlying genomic alterations. Recognizing patients with FA is important for therapeutic decisions, genetic counseling, and optimal clinical management. © 2018 |
| Keywords: | leukemia; dna repair; myelodysplastic syndrome; fanconi anemia; brca1/2; bone marrow failure; exquisite therapeutic sensitivity; fanconi complex |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 32 |
| Issue: | 4 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2018-08-01 |
| Start Page: | 657 |
| End Page: | 668 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2018.04.002 |
| PROVIDER: | scopus |
| PUBMED: | 30047418 |
| PMCID: | PMC6071325 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2018 -- Source: Scopus |
