Prognostic factors in adenocarcinoma of the uterine cervix Journal Article
| Authors: | Saigo, P. E.; Cain, J. M.; Kim, W. S.; Gaynor, J. J.; Johnson, K.; Lewis, J. L. Jr |
| Article Title: | Prognostic factors in adenocarcinoma of the uterine cervix |
| Abstract: | A group of 136 female patients with adenocarcinoma of the uterine cervix, treated at Memorial Sloan‐Kettering Cancer Center between 1949 and 1981, with slides available for review, formed the basis for this study. They ranged in age from 10 to 91 years. Most (73%) had abnormal bleeding, either alone or in combination with other symptoms; 15% were asymptomatic. Eighty percent had a visible abnormality, most commonly an exophytic mass. Clinical stages were: 0 (3%), IB (61%), IIA (14%), IIB (10%), III (4%). There were four major histologic subtypes: mucinous (47%), endometrioid (24%), adenosquamous (15%), and clear cell (9%) carcinoma. Of the many clinicopathologic variables evaluated for prognosis, the most significant was stage of disease (P< 0.0001). Those with Stage IB disease had a survival probability of 76% at 5 years compared with 49% for those with Stage IIA and 34% with Stage IIB. The endometrioid pattern was associated with a more favorable prognosis than any other histologic subtype (P = 0.02). The presence of lymphatic tumor emboli and/or metastatic carcinoma in any lymph node group was associated with a less favorable prognosis for patients with Stage IB and IIA disease (P < 0.0001). Cancer 57:1584–1593, 1986. Copyright © 1986 American Cancer Society |
| Keywords: | survival; adolescent; adult; child; aged; middle aged; retrospective studies; major clinical study; histopathology; cancer staging; endometrioid carcinoma; hysterectomy; lymphatic metastasis; neoplasm staging; lymph node excision; adenocarcinoma; metastasis; radiotherapy; histology; diagnosis; adenosquamous carcinoma; clear cell carcinoma; uterine cervical neoplasms; mucinous carcinoma; hormones; cervix uteri; staining and labeling; vaginal smears; continental population groups; female genital system; parity; uterine cervix adenocarcinoma; humans; prognosis; human; female; priority journal |
| Journal Title: | Cancer |
| Volume: | 57 |
| Issue: | 8 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1986-04-15 |
| Start Page: | 1584 |
| End Page: | 1593 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19860415)57:8<1584::Aid-cncr2820570825>3.0.Co;2-8 |
| PUBMED: | 2418947 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work