Peritoneal washings in endometrial carcinoma: A study of 298 patients with histopathologic correlation Journal Article
| Authors: | Gu, M.; Shi, W. J. ; Barakat, R. R.; Thaler, H. T.; Saigo, P. E. |
| Article Title: | Peritoneal washings in endometrial carcinoma: A study of 298 patients with histopathologic correlation |
| Abstract: | OBJECTIVE: To correlate findings of peritoneal washings in patients with endometrial carcinoma with histologic parameters. STUDY DESIGN: Between 1995 and 1998, 298 women with endometrial carcinoma were treated by hysterectomy with intraoperative peri toneal washings (PW) at Memorial Sloan-Kettering Cancer Center. All cytology and pathology slides were available for review. Pathologic parameters of hysterectomy specimens were evaluated and correlated with the findings of PW. RESULTS: Thirty-two patients (10.7%) had abnormal PW. Two hundred sixty-two had endometrioid adenocarcinoma; 26 of them had abnormal PW (10.0%). Thirty-six patients had other histologic subtypes (papillary serous carcinoma, clear cell carcinoma and adenosquamous carcinoma), and six of them had abnormal PW (16.7%). The incidence of abnormal PW in the two groups teas not significantly different (P =.78. Among 26 patients with endometrioid adenocarcinoma and abnormal PW, there were 17 cases (9.9%) of International Federation of Gynecology and Obstetrics (FIGO) grade 1, 7 (22.7%) of grade 2 and 2 (5.7%) of grade 3 (P = .56). Ten cases (14.9%) had no myometrial invasion, 10 (7.0%) had myometrial invasion of less than or equal to 50% of myometrial thickness, and 6 (11.5%) had invasion of > 50% of myometrial thickness (P =.18). Vascular invasion was present in 8 cases (14.8%) and absent from 17 (8.2%) (P=.14). Eighteen patients (7.6%) had stage I/II disease, and eight patients (30.8%) had stage III/IV disease (P =.001). Among 298 patients, cervicovaginal smears performed before surgery were available for review in 76. Five of the 7 patients (71.4%) with abnormal PW and 37 of the 69 patients (53.6%) with normal PW had abnormal Pap smears (P = .45). CONCLUSION: Abnormal PW did not correlate with histologic subtypes, FIGO grade, depth of myometrial invasion, vascular invasion or abnormal Pnp smears. A significantly higher incidence of abnormal PW was associated with stage III/IV disease. |
| Keywords: | endometrial neoplasms; adenocarcinoma; cytology; experience; prognostic-significance; disease; stage-i; peritoneum; peritoneal washings; cancer; pelvic washings |
| Journal Title: | Acta Cytologica |
| Volume: | 44 |
| Issue: | 5 |
| ISSN: | 0001-5547 |
| Publisher: | S. Karger AG |
| Date Published: | 2000-09-01 |
| Start Page: | 783 |
| End Page: | 789 |
| Language: | English |
| ACCESSION: | WOS:000089473200012 |
| PROVIDER: | wos |
| PUBMED: | 11015980 |
| Notes: | Article -- Source: Wos |
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