Thrombotic cerebral vasculopathy associated with herpes zoster Journal Article
| Authors: | Eidelberg, D.; Sotrel, A.; Horoupian, D. S.; Neumann, P. E.; Pumarola‐Sune, T.; Price, R. W. |
| Article Title: | Thrombotic cerebral vasculopathy associated with herpes zoster |
| Abstract: | We describe the clinical, radiographic, and pathological findings in 3 patients with large‐vessel cerebral vasculopathy following herpes zoster. Two of the patients were studied at postmortem examination, and a brain biopsy was performed in the third. Each of the 3 patients suffered thrombotic occlusions of large vessels without notable inflammatory or granulomatous changes following trigeminal or segmental herpes zoster infection. In the 2 autopsied patients, varicella‐zoster virus (VZV) antigens were detected by immunoperoxidase staining within the media of the affected cerebral arteries. Little or no inflammation was associated with the foci of the VZV antigens. These studies provide evidence that the vasculopathy following herpes zoster may result from direct VZV infection of the artery and the in situ thrombosis can develop within the infected vessels in the absence of clear inflammatory vasculitis. Copyright © 1986 American Neurological Association |
| Keywords: | adult; aged; middle aged; case report; tomography, x-ray computed; herpes zoster; histology; central nervous system; immunoenzyme techniques; thrombosis; cardiovascular system; diagnosis; virus antigen; autopsy; brain biopsy; histocytochemistry; etiology; varicella zoster virus; antigens, viral; herpesvirus 3, human; cerebral angiography; immunoperoxidase staining; humans; human; male; female; priority journal; intracranial embolism and thrombosis; blood and hemopoietic system; peripheral vascular system; circle of willis |
| Journal Title: | Annals of Neurology |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 0364-5134 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1986-01-01 |
| Start Page: | 7 |
| End Page: | 14 |
| Language: | English |
| DOI: | 10.1002/ana.410190103 |
| PUBMED: | 3004319 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors wish to thank Dr Michael Ronthal, who encouraged this project, and Dr Michael Biber, who consulted on the second patient. Special thanks to Dr Hani A. Haykal, who reviewed the angiograms |
