Review: Cytotoxic intracavitary chemotherapy Journal Article
| Author: | Markman, M. |
| Article Title: | Review: Cytotoxic intracavitary chemotherapy |
| Abstract: | The intracavitary administration of chemotherapeutic agents for their cytotoxic properties as therapy for tumors confined to body cavities has significant theoretical appeal. Pharmacokinetic evaluation of several clinically useful antineoplastic drugs has confirmed modeling predictions that suggested a major advantage for cavity exposure to the agents compared with that of the plasma when the drugs are delivered directly into the body cavity. As the direct penetration of the agents into tissue is quite limited, the greatest potential utility of this therapeutic approach would be in patients with microscopic residual disease following debulking surgery or as therapy for patients with a high risk of intraperitoneal recurrence. Major toxicities of this innovative technique include abdominal pain (chemical serositis) and infection. Additional clinical evaluation will be required to define a role for cytotoxic intracavitary chemotherapy in the management of malignant disease. |
| Keywords: | cancer chemotherapy; clinical trial; review; cisplatin; doxorubicin; fluorouracil; antineoplastic agents; liver neoplasms; cytarabine; methotrexate; antineoplastic agent; ovarian neoplasms; animal; metabolism; animals; ovary cancer; etoposide; inflammation; colonic neoplasms; melphalan; vinblastine; abdominal pain; antiinfective agent; folinic acid; colon tumor; liver tumor; ovary tumor; mitoxantrone; catheterization; asparaginase; bleomycin; altretamine; pleura tumor; drug toxicity; drug blood level; drug administration; antibiotics, antineoplastic; mitomycin; antineoplastic antibiotic; bacterial infection; adverse drug reaction; therapy; pleural neoplasms; clinical trials; pharmacokinetics; streptozocin; cytostatic agent; peritoneum; intoxication; peritonitis; intraperitoneal drug administration; liver circulation; sodium thiosulfate; cancer; humans; human; female; priority journal |
| Journal Title: | American Journal of the Medical Sciences |
| Volume: | 291 |
| Issue: | 3 |
| ISSN: | 0002-9629 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1986-03-01 |
| Start Page: | 175 |
| End Page: | 179 |
| Language: | English |
| DOI: | 10.1097/00000441-198603000-00006 |
| PUBMED: | 3513565 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 18 August 2021 -- Source: Scopus |
