Intraperitoneal therapy in ovarian cancer utilizing agents achieving high local but low systemic exposures Journal Article

  


Author: Markman, M.
Article Title: Intraperitoneal therapy in ovarian cancer utilizing agents achieving high local but low systemic exposures
Abstract: Several cytotoxic agents, including doxorubicin, mitoxantrone, and mitomycin, have demonstrated a major pharmacokinetic advantage for peritoneal cavity exposure following intraperitoneal (i.p.) delivery. Unfortunately, systemic concentrations with this route of drug administration are very limited because of local toxic effects. Responses, including surgically documented complete remissions, are observed when this group of agents is delivered by the i.p. route as therapy for refractory ovarian cancer. However, concerns have been raised about the consequences of an inferior delivery of drug to tumor by capillary flow with local therapy owing to a decrease in systemic exposure. Clinical strategies to optimize the use of this therapeutic approach with drugs that produce high local concentrations but low systemic exposures are presented.
Keywords: review; cisplatin; doxorubicin; fluorouracil; antineoplastic agent; carboplatin; ovary cancer; melphalan; mitoxantrone; mitomycin; liposome; intravenous drug administration; intraperitoneal drug administration; human; female
Journal Title: Regional Cancer Treatment
Volume: 3
Issue: 5
ISSN: 0935-0411
Publisher: Springer  
Date Published: 1991-02-01
Start Page: 264
End Page: 268
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025982127&partnerID=40&md5=b85eb85f161d6bff59c13394dbe9f116
Notes: Review -- Source: Scopus