Multipoint linkage analysis Journal Article
| Authors: | Morton, N. E.; MacLean, C. J.; Lew, R.; Yee, S. |
| Article Title: | Multipoint linkage analysis |
| Abstract: | A formula is given for the advantage of n-point sampling, which approaches infinity with n. However, 2-point and 3-point analyses extract nearly all the information in such samples and at the same time communicate this information as lods and χ2, which can be combined with other data by simple addition without reevaluation of the likelihood. When null interference is assumed, map distances and multiple recombination frequencies are inflated, and there is substantial loss of efficiency and of support for the correct order. |
| Keywords: | methodology; animal; heredity; statistics; gene mapping; probability; diagnosis; x chromosome; models, genetic; drosophila melanogaster; linkage (genetics); genetic linkage; genetic markers; chromosome mapping; computer analysis; restriction fragment length polymorphism; normal value; human; male; priority journal; support, u.s. gov't, p.h.s. |
| Journal Title: | American Journal of Human Genetics |
| Volume: | 38 |
| Issue: | 6 |
| ISSN: | 0002-9297 |
| Publisher: | Cell Press |
| Date Published: | 1986-06-01 |
| Start Page: | 868 |
| End Page: | 883 |
| Language: | English |
| PUBMED: | 3088988 |
| PROVIDER: | scopus |
| PMCID: | PMC1684851 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
