Chromatin remodeling and cancer, part I: Covalent histone modifications Journal Article
| Authors: | Wang, G. G.; Allis, C. D.; Chi, P. |
| Article Title: | Chromatin remodeling and cancer, part I: Covalent histone modifications |
| Abstract: | Dynamic chromatin remodeling underlies many, if not all, DNA-templated biological processes, including gene transcription; DNA replication and repair; chromosome condensation; and segregation and apoptosis. Disruption of these processes has been linked to the development and progression of cancer. The mechanisms of dynamic chromatin remodeling include the use of covalent histone modifications, histone variants, ATP-dependent complexes and DNA methylation. Together, these mechanisms impart variation into the chromatin fiber, and this variation gives rise to an 'epigenetic landscape' that extends the biological output of DNA alone. Here, we review recent advances in chromatin remodeling, and pay particular attention to mechanisms that appear to be linked to human cancer. Where possible, we discuss the implications of these advances for disease-management strategies. © 2007 Elsevier Ltd. All rights reserved. |
| Keywords: | protein phosphorylation; review; dna replication; neoplasms; animals; dna damage; dna repair; apoptosis; models, biological; serine; genetic transcription; dna methylation; carcinogenesis; dna; protein processing, post-translational; epigenetics; histone; chromatin; histone h3; chromosomal instability; adenosine triphosphate; histone h2b; protein variant; histones; lysine; chromatin assembly and disassembly; protein modification; chromosome segregation; acetylation; histone deacetylase 1; histone deacetylase 2; histone deacetylase 3; histone deacetylase 4; histone deacetylase 5; histone deacetylase 6; histone deacetylase 8; chromosome condensation |
| Journal Title: | Trends in Molecular Medicine |
| Volume: | 13 |
| Issue: | 9 |
| ISSN: | 1471-4914 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-09-01 |
| Start Page: | 363 |
| End Page: | 372 |
| Language: | English |
| DOI: | 10.1016/j.molmed.2007.07.003 |
| PUBMED: | 17822958 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 95" - "Export Date: 17 November 2011" - "CODEN: TMMRC" - "Source: Scopus" |
