Association between Chlamydia trachomatis and abnormal uterine bleeding Journal Article
| Authors: | Toth, M.; Patton, D. L.; Esquenazi, B.; Shevchuk, M.; Thaler, H.; Divon, M. |
| Article Title: | Association between Chlamydia trachomatis and abnormal uterine bleeding |
| Abstract: | Problem: The purpose was to identify distinct inflammatory markers in endometrial tissues of women with abnormal uterine bleeding (AUB) and Chlamydia trachomatis infection. Method of study: Archived endometrial specimens from 92 randomly selected premenopausal women with AUB were examined for C. trachomatis using the species-specific monoclonal antibody against major outer membrane protein (MOMP) and for histopathology associated with inflammation. Statistical analyses included single and multiple logistic regression. Diagnostic accuracy was summarized using receiver operating characteristic (ROC) curves. Results: Chlamydia trachomatis was detected in 44 (48%) of 92 AUB specimens. There were statistically significant correlations of positive MOMP with higher counts of plasma cells (P < 0.01), macrophages (P < 0.0001), and lymphocytic foci (P = 0.01). The ROC curve for macrophages was the strongest predictor (area under the curve = 0.82) for C. trachomatis. Conlusion: The prevalence of C. trachomatis in women with AUB is under-estimated. Macrophages appear to be a strong marker for the presence of C. trachomatis in the endometrium. © 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. |
| Keywords: | adolescent; adult; controlled study; human tissue; middle aged; retrospective studies; major clinical study; histopathology; area under the curve; nonhuman; conference paper; diagnostic accuracy; sensitivity and specificity; logistic models; prevalence; inflammation; monoclonal antibody; plasma cell; antibodies, monoclonal; statistical analysis; bacterium detection; predictive value of tests; multivariate logistic regression analysis; cell count; premenopause; macrophage; macrophages; lymphocyte; lymphocytes; roc curve; plasma cells; endometrium; receiver operating characteristic; bacterial outer membrane proteins; outer membrane protein; abnormal uterine bleeding; chlamydia trachomatis; chlamydiasis; endometritis; uterus bleeding; chlamydia infections; metrorrhagia |
| Journal Title: | American Journal of Reproductive Immunology |
| Volume: | 57 |
| Issue: | 5 |
| ISSN: | 1046-7408 |
| Publisher: | Blackwell Publishing |
| Date Published: | 2007-05-01 |
| Start Page: | 361 |
| End Page: | 366 |
| Language: | English |
| DOI: | 10.1111/j.1600-0897.2007.00481.x |
| PUBMED: | 17430500 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: AAJID" - "Source: Scopus" |
