Isolated splenic high-grade serous carcinoma: A case report Journal Article
| Authors: | Rogers, R.; Ehmann, S.; Tew, W. P.; Broach, V. |
| Article Title: | Isolated splenic high-grade serous carcinoma: A case report |
| Abstract: | We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation. © 2021 The Authors |
| Keywords: | adult; clinical article; human tissue; middle aged; unclassified drug; gene mutation; sequence analysis; somatic mutation; drug tolerability; fatigue; histopathology; splenectomy; case report; cancer combination chemotherapy; treatment duration; paclitaxel; positron emission tomography; laparotomy; cytoreductive surgery; carboplatin; computer assisted tomography; multiple cycle treatment; tumor volume; carcinoembryonic antigen; tumor differentiation; tumor biopsy; mutational analysis; protein p53; abdominal pain; intraoperative period; splenomegaly; tumor protein; hypermetabolism; carcinoma; thorax radiography; ca 125 antigen; abdominal hysterectomy; fluorodeoxyglucose; distal pancreatectomy; abdominal radiography; tumor necrosis; esophagogastroduodenoscopy; tumor calcinosis; peptides and proteins; omentectomy; pelvis radiography; radical resection; endoscopic ultrasonography; magnetic resonance cholangiopancreatography; spleen cancer; high-grade serous carcinoma; normal value; cancer test; human; female; article; hotspot mutation; positron emission tomography-computed tomography; partner and localizer of brca2; arid1 somatic mutation; palb2 mutation; pluripotent spleen cell; splenic mullerian carcinoma; tp53 hotspot mutation; arid1 protein; abnormal value; bilateral salpingo-oophorectomy; memorial sloan kettering integrated mutation profiling of actionable cancer targets; mullerian high grade serous carcinoma; multigene tumor panel test; spleen biopsy; ultrasound guided biopsy |
| Journal Title: | Gynecologic Oncology Reports |
| Volume: | 37 |
| ISSN: | 2352-5789 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2021-08-01 |
| Start Page: | 100818 |
| Language: | English |
| DOI: | 10.1016/j.gore.2021.100818 |
| PROVIDER: | scopus |
| PMCID: | PMC8253960 |
| PUBMED: | 34258358 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2021 -- Source: Scopus |
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