Mixed mesonephric adenocarcinoma and high-grade neuroendocrine carcinoma of the uterine cervix: Case description of a previously unreported entity with insights into its molecular pathogenesis Journal Article

   

Authors:	Cavalcanti, M. S.; Schultheis, A. M.; Ho, C.; Wang, L.; DeLair, D. F.; Weigelt, B.; Gardner, G.; Lichtman, S. M.; Hameed, M.; Park, K. J.
Article Title:	Mixed mesonephric adenocarcinoma and high-grade neuroendocrine carcinoma of the uterine cervix: Case description of a previously unreported entity with insights into its molecular pathogenesis
Abstract:	Human papillomavirus (HPV)-negative cervical carcinomas are uncommon and typically encompass unusual histologic subtypes. Mesonephric adenocarcinoma is one such subtype. Mesonephric tumors in the female genital tract are thought to arise from Wolffian remnants, and are extremely rare tumors with widely variable morphology. Sarcomatoid dedifferentiation has been previously described in a few cases, but other forms of dedifferentiation have not been reported. Neuroendocrine carcinoma of the cervix (e.g. small cell carcinoma) is associated with HPV infection, typically HPV 18. These tumors often arise in association with a conventional epithelial component such as squamous cell carcinoma or usual-type endocervical adenocarcinoma. We describe a case of mesonephric adenocarcinoma of the uterine cervix associated with an HPV-negative high-grade neuroendocrine carcinoma at the morphologic and immunophenotypic level, for which we performed targeted massively parallel sequencing analysis of the 2 elements. Both components shared identical mutations in U2AF1 p.R156H (c.467G>A) and GATA3 p.M422fs (c.1263dupG), as well as MYCN amplification. In addition, the neuroendocrine carcinoma harbored TP53 and MST1R mutations not present in the mesonephric carcinoma. Our data suggest a clonal origin of the 2 components of this rare entity, rather than a collision tumor. © 2016 International Society of Gynecological Pathologists.
Keywords:	uterine cervix; neuroendocrine; molecular; human papillomavirus; mesonephric
Journal Title:	International Journal of Gynecological Pathology
Volume:	36
Issue:	1
ISSN:	0277-1691
Publisher:	Lippincott Williams & Wilkins
Date Published:	2017-01-01
Start Page:	76
End Page:	89
Language:	English
DOI:	10.1097/pgp.0000000000000306
PROVIDER:	scopus
PUBMED:	27532149
PMCID:	PMC5500437
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983042547&doi=10.1097%2fPGP.0000000000000306&partnerID=40&md5=1717d70c5d8e2ea66596069159a9304e
Notes:	Article -- Export Date: 3 January 2017 -- Source: Scopus

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