Sarcoma Journal Article


Authors: Skubitz, K. M.; D'adamo, D. R.
Article Title: Sarcoma
Abstract: Sarcomas comprise a heterogeneous group of mesenchymal neoplasms. They can be grouped into 2 general categories, soft tissue sarcoma and primary bone sarcoma, which have different staging and treatment approaches. This review includes a discussion of both soft tissue sarcomas (malignant fibrous histiocytoma, liposarcoma, leiomyosarcoma, synovial sarcoma, dermatofibrosarcoma protuberans, angiosarcoma, Kaposi sarcoma, gastrointestinal stromal tumor, aggressive fibromatosis or desmoid tumor, rhabdomyosarcoma, and primary alveolar soft-part sarcoma) and primary bone sarcomas (osteosarcoma, Ewing sarcoma, giant cell tumor, and chondrosarcoma). The 3 most important prognostic variables are grade, size, and location of the primary tumor. The approach to a patient with a sarcoma begins with a biopsy that obtains adequate tissue for diagnosis without interfering with subsequent optimal definitive surgery. Subsequent treatment depends on the specific type of sarcoma. Because sarcomas are relatively uncommon yet comprise a wide variety of different entities, evaluation by oncology teams who have expertise in the field is recommended. Treatment and follow-up guidelines have been published by the National Comprehensive Cancer Network (www.nccn.org). © 2007 Mayo Foundation for Medical Education and Research.
Keywords: osteosarcoma; bone neoplasms; cisplatin; doxorubicin; skin toxicity; antineoplastic agents; conference paper; gemcitabine; paclitaxel; methotrexate; temozolomide; topotecan; follow up; neoplasm staging; gastrointestinal stromal tumor; imatinib; dacarbazine; nephrotoxicity; bone marrow suppression; etoposide; antineoplastic combined chemotherapy protocols; risk factors; cytogenetics; cyclophosphamide; practice guideline; tumor biopsy; angiosarcoma; risk factor; ifosfamide; vinblastine; docetaxel; irinotecan; ewing sarcoma; sarcoma; hypoxia; nonsteroid antiinflammatory agent; sulindac; cardiotoxicity; neoplasm metastasis; dactinomycin; soft tissue sarcoma; bleomycin; tamoxifen; predictor variable; mitomycin c; kaposi sarcoma; chromosome aberrations; trabectedin; leiomyosarcoma; malignant fibrous histiocytoma; rhabdomyosarcoma; synovial sarcoma; anthracycline; alopecia; chondrosarcoma; soft tissue neoplasms; antiestrogen; liposarcoma; desmoid tumor; dermatofibrosarcoma protuberans; fibromatosis; giant cell tumor; gemcitabine triphosphate
Journal Title: Mayo Clinic Proceedings
Volume: 82
Issue: 11
ISSN: 0025-6196
Publisher: Mayo Clinic Proceedings  
Date Published: 2007-11-01
Start Page: 1409
End Page: 1432
Language: English
DOI: 10.4065/82.11.1409
PUBMED: 17976362
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 58" - "Export Date: 17 November 2011" - "CODEN: MACPA" - "Source: Scopus"
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MSK Authors
  1. David R D'Adamo
    37 D'Adamo