Local ablative therapies to metastatic soft tissue sarcoma Journal Article


Authors: Gronchi, A.; Guadagnolo, B. A.; Erinjeri, J. P.
Article Title: Local ablative therapies to metastatic soft tissue sarcoma
Abstract: The approach to metastatic soft tissue sarcoma is complex and depends upon several factors, such as the extent of the disease, the histologic subtype of the primary tumor, the disease-free interval, patient status and comorbidities, and previous treatments. The effect of systemic chemotherapy is suboptimal, therefore local ablative therapies are often considered when the disease is limited, especially if confined to a single site/organ. Historically, surgery has been considered the treatment of choice for isolated lung metastases. This approach also has been extended to metastases in the liver, although a formal demonstration of its benefit has never been provided. Radiation therapy instead has been mainly used to obtain pain control and to reduce the risk of bone fracture and cord compression. Advances in techniques, such as the development of more precise conformational modalities and the employment of particles, may change the role of this modality in the strategic approach to metastatic soft tissue sarcoma. Recently, the use of interventional radiology in this scenario has expanded. Ablative approaches, such as radiofrequency ablation and cryoablation, have shown durable eradication of tumors. Catheter-directed therapies, such as hepatic artery embolization, are potential techniques for treating the patient who has multiple unresectable liver metastases. Understanding the timing and role of these three different modalities in the multidisciplinary approach to metastatic soft tissue sarcoma is critical to provide better care and to personalize the approach to the single patient.
Keywords: disease-free survival; liver neoplasms; disease free survival; metastasis; lung neoplasms; pathology; sarcoma; neoplasm metastasis; catheter ablation; secondary; humans; human
Journal Title: American Society of Clinical Oncology Educational Book
Volume: 36
ISSN: 1548-8756
Publisher: American Society of Clinical Oncology  
Date Published: 2016-05-01
Start Page: e566
End Page: e575
Language: English
DOI: 10.14694/EDBK_157450
PUBMED: 27249769
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 2 May 2017 -- Source: Scopus
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  1. Joseph Patrick Erinjeri
    112 Erinjeri