Bronchiolar adenoma/pulmonary ciliated muconodular papillary tumor: Potential pitfall on frozen sections Journal Article
| Authors: | Shirsat, H.; Zhou, F.; Chang, J. C.; Rekhtman, N.; Saqi, A.; Argyropoulos, K.; Azour, L.; Simms, A.; Melamed, J.; Hung, Y. P.; Roden, A. C.; Mino-Kenudson, M.; Moreira, A. L.; Narula, N. |
| Article Title: | Bronchiolar adenoma/pulmonary ciliated muconodular papillary tumor: Potential pitfall on frozen sections |
| Abstract: | Objectives: To describe the histologic features that are helpful in the diagnosis of the rare bronchiolar adenomas/ciliated muconodular papillary tumors (BAs/CMPTs) during intraoperative consultation. Methods: Multi-institutional retrospective review of frozen sections of 18 BAs/CMPTs. Results: In 14 of 18 cases, BA/CMPT was the primary reason for sublobar lung resection, and in 4 cases, BA/CMPT was an incidental finding intraoperatively for resections performed for carcinoma in other lobes. There were 11 proximal-type/classic BAs/CMPTs and 7 distal-type/nonclassic BAs/CMPTs. Only 3 (16.7%) of 18 were correctly diagnosed at the time of frozen section, all of which were proximal type/classic. The remainder were diagnosed as adenocarcinoma (n = 7); invasive mucinous adenocarcinoma (n = 1); non-small cell lung carcinoma (n = 1); cystic mucinous neoplasm, favor adenocarcinoma (either mucinous or colloid type) (n = 1); favor adenocarcinoma, cannot exclude CMPT (n = 1); atypical proliferation (n = 2); mucinous epithelial proliferation (n = 1); and mucous gland adenoma (n = 1). Conclusions: BA/CMPT can potentially be misdiagnosed as carcinoma during intraoperative consultation. On retrospective review of the frozen sections, the presence of the following may help to avoid misdiagnosis: a mixture of bland ciliated columnar cells, mucinous cells, and, most important, a basal cell layer, as well as a lack of necrosis, significant atypia, and mitoses. |
| Keywords: | adenocarcinoma; biopsy; adenoma; lung; braf; papillary; frozen; ciliated; muconodular; bronchiolar |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 155 |
| Issue: | 6 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2021-06-01 |
| Start Page: | 832 |
| End Page: | 844 |
| Language: | English |
| ACCESSION: | WOS:000656147200008 |
| DOI: | 10.1093/ajcp/aqaa194 |
| PROVIDER: | wos |
| PUBMED: | 33313677 |
| Notes: | Article -- Source: Wos |
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