Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study Journal Article
| Authors: | Shearer, J. J.; Sandler, D. P.; Andreotti, G.; Murata, K.; Shrestha, S.; Parks, C. G.; Liu, D.; Alavanja, M. C.; Landgren, O.; Beane Freeman, L. E.; Hofmann, J. N. |
| Article Title: | Pesticide use and kidney function among farmers in the Biomarkers of Exposure and Effect in Agriculture study |
| Abstract: | Background: Pesticides have been reported to be associated with malignant and non-malignant kidney disease. Few studies have examined the relationship between individual pesticides and kidney dysfunction. Objective: We evaluated the associations of pesticide use with measured kidney function among male pesticide applicators in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study, a subcohort in the Agricultural Health Study. Methods: Serum creatinine was measured in 1545 BEEA participants and estimated glomerular filtration rate (eGFR) was calculated with the chronic kidney disease epidemiology collaboration (CKD-EPI) equation. Using reported information on lifetime use of 41 pesticides, multivariable linear and logistic regression was used to examine associations with eGFR modeled continuously and with CKD (eGFR <60 mL/min/1.73 m2), respectively. Models were adjusted for possible confounding factors related to kidney function and correlated pesticides. Results: Lower eGFR was observed among pesticide applicators who ever used the herbicides pendimethalin (−3.7%, 95% confidence interval (CI): 5.8%, −1.5%), atrazine (−3.7%, 95% CI: 6.9%, −0.4%), and dicamba (−2.8%, 95% CI: 5.3%, −0.2%) compared with never users of each pesticide. Ever use of pendimethalin (odds ratio (OR)=1.6, 95% CI: 1.1, 2.2) and atrazine (OR=1.8, 95% CI: 1.0, 3.0) was also associated with elevated odds of CKD, with an exposure-response association between intensity-weighted lifetime days of pendimethalin use and CKD among active farmers (N=1302; ptrend=0.04). Atrazine use within the last year was associated with lower eGFR and elevated odds of CKD when compared with never users, and we observed exposure-response associations with intensity-weighted lifetime days among recent users. Use of several other pesticides was associated with higher eGFR. Discussion: These results suggest that two widely used herbicides, pendimethalin and atrazine, may be associated with altered kidney function among pesticide applicators. Our findings for these herbicides are consistent with observed associations with end-stage renal disease in the Agricultural Health Study. © 2021 |
| Keywords: | adult; controlled study; human tissue; aged; middle aged; major clinical study; biological marker; smoking; creatinine blood level; confidence interval; questionnaire; body mass; kidney function; biomarker; diabetes mellitus; multivariate analysis; carbon tetrachloride; alcohol consumption; regression analysis; serum; chronic kidney failure; estimation method; chlordane; chlorphenotane; dieldrin; lindane; occupational exposure; permethrin; correlation; agriculture; filtration; pesticides; pesticide; agricultural worker; petroleum derivative; end stage renal disease; estimated glomerular filtration rate; 2,4,5 trichlorophenoxyacetic acid; captan; human; male; priority journal; article; paraquat; 2,4 dichlorophenoxyacetic acid; farmers; ckd; alachlor; aldrin; atrazine; butylate; campheclor; carbaril; carbofuran; carbon disulfide; chlorimuron ethyl; chlorpyrifos; coumafos; cyanazine; dicamba; dichlorvos; dimpylate; fenoprop; fonofos; glyphosate; heptachlor; malathion; metalaxyl; methyl bromide; metolachlor; metribuzin; parathion methyl; pendimethalin; phorate; terbufos; trifluralin; chronic wasting disease |
| Journal Title: | Environmental Research |
| Volume: | 199 |
| ISSN: | 0013-9351 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-08-01 |
| Start Page: | 111276 |
| Language: | English |
| DOI: | 10.1016/j.envres.2021.111276 |
| PUBMED: | 33989625 |
| PROVIDER: | scopus |
| PMCID: | PMC8489787 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 July 2021 -- Source: Scopus |
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