Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption Journal Article
| Authors: | Scope, A.; Agero, A. L. C.; Dusza, S. W.; Myskowski, P. L.; Lieb, J. A.; Saltz, L.; Kemeny, N. E.; Halpern, A. C. |
| Article Title: | Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption |
| Abstract: | Purpose: To evaluate the ability of either oral minocycline, topical tazarotene or both, to reduce or prevent cetuximab-related acneiform rash when administered starting on day 1 of cetuximab therapy. Patients and Methods: Metastatic colorectal cancer patients preparing to initiate cetuximab were randomly assigned to receive daily oral minocycline or placebo, and to receive topical tazarotene application to either left or right side of the face. Both therapies were administered for 8 weeks. Results: Forty-eight eligible patients were randomly assigned to minocycline (n = 24) or placebo (n = 24). Total facial lesion counts were significantly lower in patients receiving minocycline at weeks 1 through 4. At week 4, a lower proportion of patients in the minocycline arm reported moderate to severe itch than in the placebo arm (20% v 50%, P = .05). Facial photographs, obtained at week 4, were reviewed for rash global severity. Patients in the minocycline arm trended toward lower frequency of moderate to severe rash than patients receiving placebo (20% v 42%, P = .13). The differences in total facial lesion counts and subjectively assessed itch were diminished by week 8. Cetuximab treatment was interrupted because of grade 3 skin rash in four patients in the placebo arm, and none in the minocycline arm. There was no observed clinical benefit to tazarotene application. Tazarotene treatment was associated with significant irritation, causing its discontinuation in one third of patients. Conclusion: Prophylaxis with oral minocycline may be useful in decreasing the severity of the acneiform rash during the first month of cetuximab treatment. Topical tazarotene is not recommended for management of cetuximab-related rash. © 2007 by the American Society of Clinical Oncology. |
| Keywords: | adult; cancer chemotherapy; clinical article; controlled study; aged; aged, 80 and over; middle aged; antibiotic agent; clinical trial; placebo; drug withdrawal; antineoplastic agents; colorectal cancer; metastasis; controlled clinical trial; randomized controlled trial; bedtime dosage; administration, topical; receptor, epidermal growth factor; cetuximab; nail disease; rash; colorectal neoplasms; antibodies, monoclonal; disease severity; evening dosage; morning dosage; prophylaxis; acne; double blind procedure; double-blind method; administration, oral; dry skin; minocycline; mucosal disease; placebos; acneiform eruptions; dermatologic agents; tazarotene; cefalexin; skin irritation; nicotinic acids |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 25 |
| Issue: | 34 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2007-12-01 |
| Start Page: | 5390 |
| End Page: | 5396 |
| Language: | English |
| DOI: | 10.1200/jco.2007.12.6987 |
| PUBMED: | 18048820 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 84" - "Export Date: 17 November 2011" - "CODEN: JCOND" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work