A prospective randomized trial of topical pimecrolimus for cetuximab-associated acnelike eruption Journal Article
| Authors: | Scope, A.; Lieb, J. A.; Dusza, S. W.; Phelan, D.; Myskowski, P.; Saltz, L.; Halpern, A. C. |
| Article Title: | A prospective randomized trial of topical pimecrolimus for cetuximab-associated acnelike eruption |
| Abstract: | Background: Clinical trials addressing the acneiform rash associated with epidermal growth factor receptor inhibitors are lacking. Objective: We evaluated the ability of topical pimecrolimus to reduce the severity of cetuximab-related facial rash. Methods: In all, 24 patients with metastatic colorectal cancer with cetuximab facial rash received twice daily pimecrolimus application for 5 weeks to half of the face. At baseline, week 2, and week 5, a dermatologist performed facial lesion counts, patients reported perceived severity of rash-related symptoms, and standardized facial photographs were obtained for blinded evaluation of global rash severity. Results: Treatment sides had greater decrease in lesion counts than observation sides of face at weeks 2 (P < .001) and 5 (P = .02). However, there were no significant differences in patients' assessment of symptoms and in review of facial photographs for rash severity between treatment and observation sides. Limitations: This study was not placebo controlled. Conclusions: Pimecrolimus application did not translate into clinically meaningful benefit for patients with cetuximab-related facial rash. © 2009 American Academy of Dermatology, Inc. |
| Keywords: | adult; clinical article; controlled study; aged; middle aged; treatment failure; young adult; clinical trial; antineoplastic agents; prospective study; prospective studies; colorectal cancer; controlled clinical trial; randomized controlled trial; administration, topical; cetuximab; pruritus; rash; colorectal neoplasms; standard; symptom; antibodies, monoclonal; disease severity; acne; burn; erythema; randomization; tacrolimus; photography; disease exacerbation; allergic reaction; perception; drug eruptions; acneiform eruptions; acnelike rash; pimecrolimus; face injury; observation; dermatologic agents |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 61 |
| Issue: | 4 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2009-10-01 |
| Start Page: | 614 |
| End Page: | 620 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2009.03.046 |
| PUBMED: | 19646778 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 30 November 2010" - "CODEN: JAADD" - "Source: Scopus" |
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