The Genitourinary Pathology Society update on classification of variant histologies, T1 substaging, molecular taxonomy, and immunotherapy and PD-L1 testing implications of urothelial cancers Review

  

Authors:	Compérat, E.; Amin, M. B.; Epstein, J. I.; Hansel, D. E.; Paner, G.; Al-Ahmadie, H.; True, L.; Bayder, D.; Bivalacqua, T.; Brimo, F.; Cheng, L.; Cheville, J.; Dalbagni, G.; Falzarano, S.; Gordetsky, J.; Guo, C.; Gupta, S.; Hes, O.; Iyer, G.; Kaushal, S.; Kunju, L.; Magi-Galluzzi, C.; Matoso, A.; McKenney, J.; Netto, G. J.; Osunkoya, A. O.; Pan, C. C.; Pivovarcikova, K.; Raspollini, M. R.; Reis, H.; Rosenberg, J.; Roupret, M.; Shah, R. B.; Shariat, S. F.; Trpkov, K.; Weyerer, V.; Zhou, M.; Reuter, V.
Review Title:	The Genitourinary Pathology Society update on classification of variant histologies, T1 substaging, molecular taxonomy, and immunotherapy and PD-L1 testing implications of urothelial cancers
Abstract:	The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in bladder cancer focusing on important topics of high interest for the practicing surgical pathologist and urologist. This review represents the second of 2 manuscripts ensuing from this effort. Herein, we address the effective reporting of bladder cancer, focusing particularly on newly published data since the last 2016 World Health Organization (WHO) classification. In addition, this review focuses on the importance of reporting bladder cancer with divergent differentiation and variant (subtypes of urothelial carcinoma) histologies and the potential impact on patient care. We provide new recommendations for reporting pT1 staging in diagnostic pathology. Furthermore, we explore molecular evolution and classification, emphasizing aspects that impact the understanding of important concepts relevant to reporting and management of patients. © 2021 Lippincott Williams and Wilkins. All rights reserved.
Keywords:	pathology; bladder cancer; immunotherapy; urothelial carcinoma; stage; who classification; subtypes; variant histology; molecular classification of bladder cancer; ptnm
Journal Title:	Advances in Anatomic Pathology
Volume:	28
Issue:	4
ISSN:	1072-4109
Publisher:	Lippincott Williams & Wilkins
Date Published:	2021-07-01
Start Page:	196
End Page:	208
Language:	English
DOI:	10.1097/pap.0000000000000309
PUBMED:	34128484
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108193665&doi=10.1097%2fPAP.0000000000000309&partnerID=40&md5=a013554e283d474002bcca9e733c36f4
Notes:	Review -- Erratum issued, see DOI: 10.1097/PAP.0000000000000330 -- Export Date: 1 July 2021 -- Source: Scopus

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