Treatment of hereditary breast cancer Journal Article
| Author: | Robson, M. E. |
| Article Title: | Treatment of hereditary breast cancer |
| Abstract: | Mutations in BRCA1 and BRCA2 are well-established causes of hereditary breast cancer. As genetic testing becomes more widespread, increasing numbers of women are known to have mutations at or shortly after their breast cancer diagnosis. Current evidence is insufficient to mandate different local or systemic treatment based upon the presence of a germline mutation. The well-documented increased risk of contralateral second primary breast cancer and possibly of late ipsilateral second primary breast cancers may influence patient decision-making with regard to breast-conserving treatment. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | controlled study; gene mutation; human cell; major clinical study; cisplatin; doxorubicin; cancer risk; antineoplastic agents; paclitaxel; cancer radiotherapy; radiotherapy, adjuvant; cancer diagnosis; genetic predisposition to disease; breast cancer; etoposide; breast neoplasms; brca1 protein; brca2 protein; oncogene; dna; conservative treatment; outcomes research; patient decision making; familial cancer; second cancer; mitomycin; genetic screening; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; breast surgery |
| Journal Title: | Seminars in Oncology |
| Volume: | 34 |
| Issue: | 5 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-10-01 |
| Start Page: | 384 |
| End Page: | 391 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2007.07.011 |
| PUBMED: | 17920892 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: SOLGA" - "Source: Scopus" |
