Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines Journal Article
| Authors: | Ramajayam, R.; Giridhar, R.; Yadav, M. R.; Djaballah, H.; Shum, D.; Radu, C. |
| Article Title: | Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines |
| Abstract: | Novel substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines and 4,6-diaryl-2-aminopyrimidines were synthesized and tested for their antiproliferative activity. Title compounds were obtained by cyclocondensation of a substituted flavone with ethylenediamine and guanidine respectively. The cytotoxicity in vitro against various human leukemic cancer cell lines viz., Jurkat, HL60, MOLT3, NCEB-1, K562 was determined. |
| Keywords: | controlled study; unclassified drug; human cell; cytotoxic agent; antineoplastic agents; antineoplastic agent; cell proliferation; cancer cell culture; cytotoxicity; drug structure; in vitro study; cell line, tumor; drug synthesis; structure activity relation; pyrimidines; structure-activity relationship; cancer inhibition; polymerization; molecular structure; leukemia cell line; antiproliferative activity; cell strain k 562; guanidine; diaryldiazepines; azepines; cell strain hl 60; diarylpyrimidines; 4 (2 hydroxyphenyl) 6 (2 chlorophenyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (2 furyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (2 thienyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (3 chlorophenyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (3 methoxyphenyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (4 chlorophenyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (4 fluorophenyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (4 methoxyphenyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 (4 methylphenyl) 2 aminopyrimidine; 4 (2 hydroxyphenyl) 6 phenyl 2 aminopyrimidine; 4,6 diaryl 2 aminopyrimidine derivative; 5 (2 hydroxyphenyl) 7 (2 chlorophenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (2 furyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (2 thienyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (3 chlorophenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (3 methoxyphenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (3 methylphenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (4 chlorophenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (4 fluorophenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (4 methoxyphenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 (4 methylphenyl) 2,3 dihydro 1h 1,4 diazepine; 5 (2 hydroxyphenyl) 7 phenyl 2,3 dihydro 1h 1,4 diazepine; 5,7 diaryl 2,3 dihydro 1,4 diazepine derivative; ethylenediamine; flavone |
| Journal Title: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Volume: | 22 |
| Issue: | 6 |
| ISSN: | 1475-6366 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2007-12-01 |
| Start Page: | 716 |
| End Page: | 721 |
| Language: | English |
| DOI: | 10.1080/14756360701306073 |
| PUBMED: | 18237024 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: JEIMA" - "Source: Scopus" |
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