P120 catenin is required for thickening of Schwann cell myelin Journal Article
| Authors: | Perrin-Tricaud, C.; Rutishauser, U.; Tricaud, N. |
| Article Title: | P120 catenin is required for thickening of Schwann cell myelin |
| Abstract: | Schwann cell myelin is comprised of compacted membrane regions and cytoplasmic regions with non-compacted membrane. While adherens junctions (AJ) are abundant in non-compact regions, their role in the myelination process is largely undefined. To explore this issue, a small inhibitory hairpin RNA directed against p120ctn has been delivered using adenovirus infection of Schwann cells at early stages of myelination in vivo. With strong and specific reduction in p120ctn levels for over 2 months, (a) the adherens junctions of the infected cells were reduced in size and immature with respect to recruitment of α-catenin; and (b) the formation of Schmidt-Lanterman incisures was prevented and there was a marked reduction in the thickness of the myelin sheath without a change in internodal length. These data show that p120ctn is necessary in the myelinating Schwann cell for the formation of mature adherens junctions and a normal myelin sheath. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | controlled study; dna-binding proteins; nonhuman; mouse; animals; mice; microscopy, electron; gene targeting; cell maturation; animal experiment; animal model; mice, mutant strains; rna, small interfering; in vivo study; genetic vectors; molecular sequence data; phosphoproteins; base sequence; cell adhesion molecules; plasmids; gene silencing; adenovirus vector; schwann cell; cell junction; cadherins; short hairpin rna; myelination; adenoviridae; adherens junctions; schwann cells; alpha catenin; myelin sheath; thickness; catenin; protein p120; gene delivery system |
| Journal Title: | Molecular and Cellular Neuroscience |
| Volume: | 35 |
| Issue: | 1 |
| ISSN: | 1044-7431 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2007-05-01 |
| Start Page: | 120 |
| End Page: | 129 |
| Language: | English |
| DOI: | 10.1016/j.mcn.2007.02.010 |
| PUBMED: | 17382558 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: MOCNE" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
2Tricaud -
70Rutishauser
Related MSK Work