Chemistry and biology in search of antimetastatic agents Journal Article
| Authors: | Perez, L.; Danishefsky, S. J. |
| Article Title: | Chemistry and biology in search of antimetastatic agents |
| Abstract: | A recent publication is a great example of the inherent potential of exploring the chemical space inspired by natural products. Expanding access to chemical space through organic synthesis allows the discovery of valuable new small-molecule mediators of biological activity. © 2007 by American Chemical Society. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; antineoplastic agents; antineoplastic agent; cancer susceptibility; metastasis; breast cancer; protein targeting; cancer cell culture; drug potency; drug structure; drug screening; drug design; drug synthesis; structure activity relation; cancer research; cancer inhibition; chemistry; drug antagonism; neoplasm metastasis; cell migration; metastasis potential; ic 50; rho guanine nucleotide binding protein; rho gtp-binding proteins; biological product; biological products; rac protein; organic chemistry; migrastatin; antimetastatic agent; isomigrastatin; macrolide 1; macrolide 3; nsc 23766 |
| Journal Title: | ACS Chemical Biology |
| Volume: | 2 |
| Issue: | 3 |
| ISSN: | 1554-8929 |
| Publisher: | American Chemical Society |
| Date Published: | 2007-03-20 |
| Start Page: | 159 |
| End Page: | 162 |
| Language: | English |
| DOI: | 10.1021/cb7000395 |
| PUBMED: | 17373763 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "Source: Scopus" |
