Clinical size is a poor predictor of invasion in melanoma of the lentigo maligna type Journal Article
| Authors: | Navarrete-Dechent, C.; Aleissa, S.; Connolly, K.; Hibler, B. P.; Dusza, S. W.; Rossi, A. M.; Lee, E.; Nehal, K. S. |
| Article Title: | Clinical size is a poor predictor of invasion in melanoma of the lentigo maligna type |
| Abstract: | Background: There are no well-defined clinical factors to predict the risk of occult invasion in melanoma of the lentigo maligna type (LM) before complete histopathologic analysis. Objective: To evaluate whether clinical size was a predictor of invasion in LM and subclinical extension. Methods: Consecutive cases of LM were recorded in a prospectively maintained database from 2006 to 2019. Patient and tumor data were recorded during initial evaluation. The LM clinical area was calculated in square millimeters (length × width). All patients were treated with staged excision. Results: We included 600 patients. The mean age was 65.9 years (standard deviation, 12.3; range, 27-95 years); 62.8% (n = 377) were men. The mean LM clinical area was 128.32 mm2 for in situ lesions versus 200.14 mm for invasive lesions (P =.1). Based on quantile regression, the median margin required for complete removal increased with LM clinical area. Limitations: The study was performed in a tertiary cancer center with possible referral bias and more complex cases. Conclusions: LM can present with variable clinical size, which may correlate with subclinical extension; however, the presence of invasion is not well estimated by LM clinical area. © 2020 American Academy of Dermatology, Inc. |
| Keywords: | adult; controlled study; human tissue; aged; cancer surgery; excision; major clinical study; cancer staging; outcome assessment; prospective study; melanoma; lentigo maligna; malignant lentigo; cancer size; clinical evaluation; invasion; head and neck; data analysis software; surgical margin; tumor invasion; lentigo maligna melanoma; breslow; prognosis; human; male; female; priority journal; article |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 84 |
| Issue: | 5 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2021-05-01 |
| Start Page: | 1295 |
| End Page: | 1301 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2020.10.023 |
| PUBMED: | 33096134 |
| PROVIDER: | scopus |
| PMCID: | PMC8046713 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 May 2021 -- Source: Scopus |
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