Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases Journal Article
| Authors: | Hazan, C.; Dusza, S. W.; Delgado, R.; Busam, K. J.; Halpern, A. C.; Nehal, K. S. |
| Article Title: | Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases |
| Abstract: | Background: Complete surgical excision for lentigo maligna (LM) and LM melanoma (LMM) in the head and neck region may be challenging because of potential significant subclinical extension. Objective: We sought to review clinical and histologic features of LM and LMM and determine surgical margin necessary for complete excision. Methods: We conducted a retrospective study of 117 LM and LMM cases treated with a staged margin-controlled excision technique with rush paraffin-embedded sections. Results: The mean total surgical margin required for excision of LM was 7.1 mm and was 10.3 mm for LMM. Of the tumors diagnosed as LM on initial biopsy specimen, 16% were found to have unsuspected invasion. Total surgical margin was associated with initial clinical lesion diameter. Limitations: Retrospective and single-institution experience are limitations. Conclusion: This study corroborates that the standard excision margins for LM and LMM are often inadequate and occult invasive melanoma occurs in LM. An excision technique with permanent sections using a team of dermatopathology and surgery that carefully examines the central tumor and the surgical margins is reliable for the treatment of LM and LMM. © 2008 American Academy of Dermatology, Inc. |
| Keywords: | adult; human tissue; aged; aged, 80 and over; middle aged; excision; retrospective studies; major clinical study; clinical feature; histopathology; cancer staging; melanoma; skin biopsy; skin neoplasms; malignant lentigo; hutchinson's melanotic freckle; retrospective study; cancer invasion; tissue section; head and neck neoplasms; cancer size; surgical procedures, operative; skin disease; neoplasm invasiveness; neoplasms, multiple primary |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 58 |
| Issue: | 1 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2008-01-01 |
| Start Page: | 142 |
| End Page: | 148 |
| Language: | English |
| DOI: | 10.1016/j.jaad.2007.09.023 |
| PUBMED: | 18029055 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "CODEN: JAADD" - "Source: Scopus" |
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