Virus-specific NK cell memory Review

   


Authors: Sheppard, S.; Sun, J. C.
Review Title: Virus-specific NK cell memory
Abstract: NK cells express a limited number of germline-encoded receptors that identify infected or transformed cells, eliciting cytotoxicity, effector cytokine production, and in some circumstances clonal proliferation and memory. To maximize the functional diversity of NK cells, the array and expression level of surface receptors vary between individual NK cell "clones" in mice and humans. Cytomegalovirus infection in both species can expand a population of NK cells expressing receptors critical to the clearance of infected cells and generate a long-lived memory pool capable of targeting future infection with greater efficacy. Here, we discuss the pathways and factors that regulate the generation and maintenance of effector and memory NK cells and propose how this understanding may be harnessed therapeutically. © 2021 Rockefeller University Press. All rights reserved.
Keywords: human cell; review; nonhuman; natural killer cell; memory; virus; human; article
Journal Title: Journal of Experimental Medicine
Volume: 218
Issue: 4
ISSN: 0022-1007
Publisher: Rockefeller University Press  
Date Published: 2021-04-05
Start Page: e20201731
Language: English
DOI: 10.1084/jem.20201731
PUBMED: 33755720
PROVIDER: scopus
PMCID: PMC7992500
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103433081&doi=10.1084%2fjem.20201731&partnerID=40&md5=3dff909ef16144c17929574dfa3510e4
Notes: Review -- Export Date: 3 May 2021 -- Source: Scopus
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MSK Authors
  1. Joseph C Sun
    131 Sun
  2. Sam Sheppard
    10 Sheppard
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