Magnetic resonance imaging-guided adaptive radiotherapy for colorectal liver metastases Review
| Authors: | Romesser, P. B.; Tyagi, N.; Crane, C. H. |
| Review Title: | Magnetic resonance imaging-guided adaptive radiotherapy for colorectal liver metastases |
| Abstract: | Technological advances have enabled well tolerated and effective radiation treatment for small liver metastases. Stereotactic ablative radiation therapy (SABR) refers to ablative dose delivery (>100 Gy BED) in five fractions or fewer. For larger tumors, the safe delivery of SABR can be challenging due to a more limited volume of healthy normal liver parenchyma and the proximity of the tumor to radiosensitive organs such as the stomach, duodenum, and large intestine. In addition to stereotactic treatment delivery, controlling respiratory motion, the use of image guidance, adaptive planning and increasing the number of radiation fractions are sometimes necessary for the safe delivery of SABR in these situations. Magnetic Resonance (MR) image-guided adaptive radiation therapy (MRgART) is a new and rapidly evolving treatment paradigm. MR imaging before, during and after treatment delivery facilitates direct visualization of both the tumor target and the adjacent normal healthy organs as well as potential intrafraction motion. Real time MR imaging facilitates non-invasive tumor tracking and treatment gating. While daily adaptive re-planning permits treatment plans to be adjusted based on the anatomy of the day. MRgART therapy is a promising radiation technology advance that can overcome many of the challenges of liver SABR and may facilitate the safe tumor dose escalation of colorectal liver metastases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
| Keywords: | treatment outcome; survival rate; review; radiation dose; nuclear magnetic resonance imaging; risk factor; patient safety; radiosensitivity; clinical effectiveness; external beam radiotherapy; stereotactic body radiation therapy; proton therapy; image guided radiotherapy; colorectal liver metastasis; human; patient risk; mri guided radiotherapy; stereotactic ablative radiation therapy |
| Journal Title: | Cancers |
| Volume: | 13 |
| Issue: | 7 |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Date Published: | 2021-04-01 |
| Start Page: | 1636 |
| Language: | English |
| DOI: | 10.3390/cancers13071636 |
| PROVIDER: | scopus |
| PMCID: | PMC8036824 |
| PUBMED: | 33915810 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 May 2021 -- Source: Scopus |
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