Multifocal strokes as the presentation of occult lung cancer Journal Article
| Authors: | Navi, B. B.; Deangelis, L. M.; Segal, A. Z. |
| Article Title: | Multifocal strokes as the presentation of occult lung cancer |
| Abstract: | Cancer patients are hypercoagulable through a variety of mechanisms and are at significant risk for ischemic stroke. Though usually occurring in the later stages of neoplastic disease, stroke can rarely be the first manifestation of an occult malignancy. We report a 46-year-old woman who presented with multiple cerebral infarctions in numerous vascular distributions, refractory to anticoagulation, and associated with systemic thromboses. These atypical features prompted a malignancy evaluation which revealed an occult lung adenocarcinoma. Our patient had a rapidly deteriorating course with recurrent strokes despite numerous anti-platelet and anti-coagulant agents, and was only responsive to chemotherapy aimed at the underlying cancer. © Springer Science+Business Media, LLC 2007. |
| Keywords: | adult; treatment outcome; middle aged; clinical feature; case report; drug withdrawal; hypertension; antineoplastic agents; paclitaxel; nuclear magnetic resonance imaging; adenocarcinoma; carboplatin; computer assisted tomography; multiple cycle treatment; thrombocytopenia; lung neoplasms; ca 19-9 antigen; tumor differentiation; lung cancer; tumor marker; cancer regression; lung adenocarcinoma; heart infarction; stroke; vein thrombosis; clopidogrel; heparin; ca 125 antigen; hypercholesterolemia; aphasia; drug substitution; speech disorder; hemiparesis; visual impairment; lymph node biopsy; lymphadenopathy; artery thrombosis; fibrinogen; antithrombocytic agent; cerebrovascular accident; lepirudin; magnetic resonance angiography; brain infarction; infarction, middle cerebral artery; anticoagulant agent; argatroban; d dimer; thrombophilia; occult cancer; dysarthria; angina pectoris; foot pain; hypercoagulability; non-bacterial thrombotic endocarditis; general condition deterioration; homonymous hemianopia; occlusive cerebrovascular disease |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 85 |
| Issue: | 3 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 2007-12-01 |
| Start Page: | 307 |
| End Page: | 309 |
| Language: | English |
| DOI: | 10.1007/s11060-007-9419-y |
| PUBMED: | 17611718 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: JNODD" - "Source: Scopus" |
