Sphingolipids and cell death Journal Article
| Authors: | Morales, A.; Lee, H.; Goñi, F. M.; Kolesnick, R.; Fernandez-Checa, J. C. |
| Article Title: | Sphingolipids and cell death |
| Abstract: | Sphingolipids (SLs) have been considered for many years as predominant building blocks of biological membranes with key structural functions and little relevance in cellular signaling. However, this view has changed dramatically in recent years with the recognition that certain SLs such as ceramide, sphingosine 1-phosphate and gangliosides, participate actively in signal transduction pathways, regulating many different cell functions such as proliferation, differentiation, adhesion and cell death. In particular, ceramide has attracted considerable attention in cell biology and biophysics due to its key role in the modulation of membrane physical properties, signaling and cell death regulation. This latter function is largely exerted by the ability of ceramide to activate the major pathways governing cell death such as the endoplasmic reticulum and mitochondria. Overall, the evidence so far indicates a key function of SLs in disease pathogenesis and hence their regulation may be of potential therapeutic relevance in different pathologies including liver diseases, neurodegeneration and cancer biology and therapy. © 2007 Springer Science + Business Media, LLC. |
| Keywords: | signal transduction; pathogenesis; review; nonhuman; neoplasms; cell proliferation; animals; cell death; cell survival; cell function; apoptosis; small interfering rna; cell differentiation; cancer therapy; carcinogenesis; endoplasmic reticulum; cell membrane; daunorubicin; liver disease; liver diseases; oxidative stress; sphingolipids; mitochondria; cell adhesion; lipid metabolism; mitochondrion; lipogenesis; membrane permeability; ceramide; nerve degeneration; neurodegenerative diseases; ceramide derivative; lipid transport; gangliosides; ganglioside; sphingosine 1 phosphate; membranes; sphingolipid; transbilayer trafficking; phase separation; second messenger systems |
| Journal Title: | Apoptosis |
| Volume: | 12 |
| Issue: | 5 |
| ISSN: | 1360-8185 |
| Publisher: | Springer |
| Date Published: | 2007-05-01 |
| Start Page: | 923 |
| End Page: | 939 |
| Language: | English |
| DOI: | 10.1007/s10495-007-0721-0 |
| PUBMED: | 17294080 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 69" - "Export Date: 17 November 2011" - "CODEN: APOPF" - "Source: Scopus" |
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