Interweaving the cell cycle machinery with cell differentiation Journal Article


Authors: Miller, J. P.; Yeh, N.; Vidal, A.; Koff, A.
Article Title: Interweaving the cell cycle machinery with cell differentiation
Abstract: A comprehensive understanding of the mechanisms coupling cell cycle exit and differentiation is important for both cancer biology and tissue development. Cancer cells can arise from either stem/progenitor cells that fail to exit the cell cycle and differentiate, or from de-differentiated cells that have re-entered the cell cycle. Much of our current understanding of this coupling is based on observations made in transformed cell lines. These studies have shown that enforcing proliferation prevents differentiation and inducing growth arrest leads to differentiation; thus, one widely-held view is that changes in cell cycle regulators simply induces cell cycle exit, a pre-requisite for differentiation. However, recent evidence indicates that cell cycle regulators can affect differentiation in other ways as well. They can have a role establishing the new transcriptional program that accompanies differentiation - in its most radical form, the molecular mechanism of arrest might even be an integral component of the differentiation program. Additionally, the regulators or mechanisms that prevent the re-entry of cells into the proliferative cycle may not be those that induce exit from the cell cycle. Our goal in this perspective is to highlight examples from our laboratory that provided a broader understanding of the types of roles that cell cycle regulators play during differentiation, beginning with the phenotypes observed in mice. ©2007 Landes Bioscience.
Keywords: signal transduction; review; nonhuman; cell proliferation; animals; cell cycle proteins; mus; cell cycle; cell differentiation; carcinogenesis; cell transformation, neoplastic; transcription regulation; cell cycle arrest; cyclin dependent kinase inhibitor; cell cycle regulation; differentiation; cdk inhibitors; oligodendroglia; cartilage cell; oligodendrocyte; chondrocyte; pocket proteins
Journal Title: Cell Cycle
Volume: 6
Issue: 23
ISSN: 1538-4101
Publisher: Taylor & Francis Inc.  
Date Published: 2007-12-01
Start Page: 2932
End Page: 2938
Language: English
PUBMED: 18000404
PROVIDER: scopus
DOI: 10.4161/cc.6.23.5042
DOI/URL:
Notes: --- - "Cited By (since 1996): 15" - "Export Date: 17 November 2011" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Andrew C Koff
    98 Koff
  2. Anxo Vidal
    7 Vidal
  3. Jeffrey P Miller
    6 Miller
  4. Nancy Yeh
    13 Yeh