Hermaphroditism in 3 chimeric mice Journal Article


Authors: McIntyre, A.; La Perle, K. M. D.
Article Title: Hermaphroditism in 3 chimeric mice
Abstract: Hermaphroditism was diagnosed in three, 6-month-old, male, chimeric mice generated by microinjection of 129/Ola XY recombinant embryonic stem cells into unsexed C57BL/6 blastocysts. Grossly, mice Nos. 1 and 2 had perigenital masses and hydrometra. All mice had unilateral ovaries and cystic endometrial hyperplasia. Mice Nos. 1 and 3 also had contralateral testes and epididymides. Histologically, mice Nos. 1 and 3 were true hermaphrodites with unilateral ovotestes, while mouse No. 2 was a pseudohermaphrodite with ovarian tissue only. The presence of a uterus with cystic endometrial hyperplasia in these mice resembles XY pseudohermaphroditism in miniature schnauzers. The mice were determined to be 95 to 100% chimeric via haircoat color; however, the presence of both male and female sex organs in these phenotypically male mice suggests otherwise. Published reports note incidences for sex chimeras and hermaphroditism in genetically engineered mice of 50% and 20%, respectively. Hermaphroditism is expected to increase as the numbers of chimeric mice rise with technical advances in genetic engineering.
Keywords: genetics; mouse; animal; animals; mice; mus; pathology; mice, inbred c57bl; physiology; transgenic mouse; c57bl mouse; mice, transgenic; animal disease; chimera; genetic engineering; cytochemistry; histocytochemistry; genetically engineered; hermaphrodite; true hermaphroditism; hermaphroditism, true; hydrometra
Journal Title: Veterinary Pathology
Volume: 44
Issue: 2
ISSN: 0300-9858
Publisher: Sage Publications  
Date Published: 2007-03-01
Start Page: 249
End Page: 252
Language: English
DOI: 10.1354/vp.44-2-249
PUBMED: 17317810
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "CODEN: VTPHA" - "Source: Scopus"
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