Breast cancer chemotherapy Journal Article
| Authors: | Mcarthur, H. L.; Hudis, C. A. |
| Article Title: | Breast cancer chemotherapy |
| Abstract: | Chemotherapy can be an integral component of the adjuvant management strategy for women with early-stage breast cancer. Modern adjuvant strategies now comprises one or more chemotherapy agents, hormonal maneuvers, immunotherapy agents, or experimental agents. The use of adjuvant chemotherapy is generally based on estimates of an individuals risk of recurrence and the expected benefit of therapy. However, risk-benefit calculations have recently become increasingly sophisticated as a result of advances in genetic testing and molecular marker identification as well as ongoing refinements in chemotherapy strategies. In this article we will review the role of important prognostic and predictive factors and the rationale for adjuvant systemic therapy and modern chemotherapy regimens in the management of women with early-stage breast cancer. © 2007 Lippincott Williams & Wilkins. |
| Keywords: | cancer chemotherapy; clinical trial; neutropenia; review; doxorubicin; fluorouracil; cancer combination chemotherapy; cancer risk; antineoplastic agents; pathophysiology; paclitaxel; cancer adjuvant therapy; chemotherapy, adjuvant; chemotherapy; methotrexate; cancer staging; methodology; antineoplastic agent; neoplasm staging; multiple cycle treatment; breast cancer; gene expression; mastectomy; tumor volume; epidermal growth factor receptor 2; tumor markers, biological; cyclophosphamide; breast neoplasms; tumor marker; histology; cancer mortality; risk; docetaxel; asthenia; drug dose escalation; febrile neutropenia; add on therapy; adjuvant chemotherapy; cardiotoxicity; breast tumor; tamoxifen; predictor variable; epirubicin; taxane derivative; estrogen receptor; trastuzumab; anastrozole; navelbine; antibiotics, antineoplastic; anthracycline; antineoplastic antibiotic; management; calculation; adjuvant; hypersensitivity; early stage |
| Journal Title: | The Cancer Journal |
| Volume: | 13 |
| Issue: | 3 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2007-05-01 |
| Start Page: | 141 |
| End Page: | 147 |
| Language: | English |
| DOI: | 10.1097/PPO.0b013e318074dc6f |
| PUBMED: | 17620762 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: CAJOC" - "Source: Scopus" |
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