Updates in adjuvant systemic treatment of breast cancer Journal Article
| Authors: | Mcarthur, H. L.; Hudis, C. A. |
| Article Title: | Updates in adjuvant systemic treatment of breast cancer |
| Abstract: | Breast cancer is a significant public health burden with more than 200,000 new cases diagnosed in the United States each year. Although many incident cases represent localized disease, a significant proportion of women with early stage breast cancer eventually experience a distant relapse and ultimately die of metastatic breast cancer complications. Consequently, investigators strive to improve the adjuvant treatment paradigm and thus, optimize outcomes for women with early stage breast cancer. Within the last year a study describing a decline in incident breast cancer cases in the United States was reported. In addition, the results from a number of notable adjuvant treatment studies were reported or updated. Innovations in taxane-containing strategies and dose dense chemotherapy strategies were prominently featured. In addition, a number of insights pertaining to the treatment of women with HER2-positive breast cancer were reported. An overview of selected recently reported studies will be reviewed here. © 2007 Elsevier Ltd. All rights reserved. |
| Keywords: | cancer chemotherapy; protein expression; clinical trial; neutropenia; review; doxorubicin; fluorouracil; placebo; drug efficacy; paclitaxel; cancer radiotherapy; chemotherapy; antineoplastic agent; cancer incidence; carboplatin; multiple cycle treatment; breast cancer; mastectomy; epidermal growth factor receptor 2; cyclophosphamide; chemosensitivity; docetaxel; adjuvant chemotherapy; cardiotoxicity; carcinoma in situ; tamoxifen; epirubicin; taxane derivative; estrogen receptor; trastuzumab; anastrozole; anthracycline; adjuvant; early stage |
| Journal Title: | Update on Cancer Therapeutics |
| Volume: | 2 |
| Issue: | 4 |
| ISSN: | 1872-115X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-12-01 |
| Start Page: | 193 |
| End Page: | 199 |
| Language: | English |
| DOI: | 10.1016/j.uct.2007.11.001 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 November 2011" - "Source: Scopus" |
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