Planning in the IGRT context: Closing the loop Journal Article
| Authors: | Mageras, G. S.; Mechalakos, J. |
| Article Title: | Planning in the IGRT context: Closing the loop |
| Abstract: | Technological developments in image-guided radiotherapy systems have introduced new considerations to the treatment-planning process. These include more rational assessment and reduction of treatment margins; adaptation of treatment plans according to information gathered as treatment progresses; and facilitation of treatments involving the delivery of large, highly focused doses of radiation to tumors. We examine the performance of different treatment-room image-guidance systems in terms of target position accuracy; such information is important for determining treatment margins and deciding on an appropriate correction strategy. Some clinical situations may warrant a modification to a patient's treatment plan part way through a course of treatment, such as tumor shrinkage in response to treatment and daily organ variation. We discuss the challenges and review proposed strategies for treatment-plan adaptation. Image guidance in combination with 3-dimensional conformal and intensity-modulated radiotherapy has provided the tools for clinical trials of single-dose and hypofractionated treatment as an alternative to standard fractionation. We discuss the clinical realization of this treatment paradigm in various disease sites. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | intensity modulated radiation therapy; treatment planning; liver neoplasms; cancer radiotherapy; radiation dose; diagnostic accuracy; neoplasms; computer assisted tomography; image analysis; lung neoplasms; radiotherapy dosage; lung cancer; tomography, x-ray computed; diagnostic imaging; prostate cancer; prostatic neoplasms; head and neck cancer; head and neck neoplasms; liver cancer; radiotherapy planning, computer-assisted; tumor; dose fractionation; image processing; computer assisted radiotherapy; image display; analytical error; cone beam computed tomography; image guided radiotherapy |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 17 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-10-01 |
| Start Page: | 268 |
| End Page: | 277 |
| Language: | English |
| DOI: | 10.1016/j.semradonc.2007.06.002 |
| PUBMED: | 17903704 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 17 November 2011" - "CODEN: SRONE" - "Source: Scopus" |
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