Pulmonary toxicity associated with erlotinib Journal Article
| Authors: | Liu, V.; White, D. A.; Zakowski, M. F.; Travis, W.; Kris, M. G.; Ginsberg, M. S.; Miller, V. A.; Azzoli, C. G. |
| Article Title: | Pulmonary toxicity associated with erlotinib |
| Abstract: | Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported. The adverse pulmonary effects of erlotinib are less well known. We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib. He had been found to have pathologic findings of usual interstitial pneumonia (UIP) on the resected lung cancer specimen prior to receiving erlotinib. This case and other published evidence should alert physicians to the possibility of fatal erlotinib-induced ILD. Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity. |
| Keywords: | middle aged; case report; erlotinib; protein kinase inhibitor; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; protein kinase inhibitors; lung tumor; chemically induced disorder; interstitial lung disease; fatal outcome; quinazolines; quinazoline derivative; fatality; lung diseases, interstitial |
| Journal Title: | Chest |
| Volume: | 132 |
| Issue: | 3 |
| ISSN: | 0012-3692 |
| Publisher: | American College of Chest Physicians |
| Date Published: | 2007-09-01 |
| Start Page: | 1042 |
| End Page: | 1044 |
| Language: | English |
| DOI: | 10.1378/chest.07-0050 |
| PUBMED: | 17873198 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "Source: Scopus" |
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