Immunotherapy for the treatment of colorectal cancer Review

  


Authors: Lumish, M. A.; Cercek, A.
Review Title: Immunotherapy for the treatment of colorectal cancer
Abstract: Immune checkpoint inhibition (ICI) has transformed the management of metastatic colorectal cancer (mCRC) with mismatch-repair deficiency (dMMR) and microsatellite instability (MSI-H), though this constitutes on average less than 5% of mCRC, and ICI is ineffective in preserved MMR/microsatellite stable disease (pMMR/MSS). Here we review the efficacy of ICI in dMMR/MSI-H mCRC, poor response to ICI in pMMR/MSS mCRC, role for ICI in locally advanced disease, biomarkers of response, novel immunotherapies, and future directions in targeting resistance mechanisms. © 2020 Wiley Periodicals LLC
Keywords: microsatellite instability; mismatch repair deficiency; checkpoint blockade; checkmate; keynote
Journal Title: Journal of Surgical Oncology
Volume: 123
Issue: 3
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2021-03-01
Start Page: 760
End Page: 774
Language: English
DOI: 10.1002/jso.26357
PROVIDER: scopus
PUBMED: 33595891
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101043160&doi=10.1002%2fjso.26357&partnerID=40&md5=28b603df60ff1edddba459a11f558891
Notes: Review -- Export Date: 1 March 2021 -- Source: Scopus
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MSK Authors
  1. Andrea Cercek Hanjis
    351 Cercek Hanjis
  2. Melissa Amy Lumish
    39 Lumish
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